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	Temporal strategy for discriminating noxious from non-noxious electrical stimuli by cortical and thalamic neural ensembles in rats
	Wang, Jin-Yan1; Chang, Jing-Yu2; Woodward, Donald J.2; Luo, Fei1; F. Luo
刊名	NEUROSCIENCE LETTERS
	2008-04-18
卷号	435期号:2页码:163-168
关键词	cortex electrical stimulation neural ensemble pain processing spike train
ISSN号	0304-3940
文献子类	Article
英文摘要	Considerable evidence supports that pain is encoded in a large, widespread network that consists of the thalamus, cortex, as well as limbic system. However, the temporal properties of the neural matrix in pain processing were largely unknown. In the present study, we simultaneously recorded thalamic and cortical neuronal discharges elicited by brief noxious or innocuous electrical stimulus in awake rats. The discrimination performance of the neural ensembles in differentiating noxious from innocuous inputs was calculated using different window sizes at the millisecond and second level, respectively. The results demonstrated that coding information emerged in a quantum-like manner; the minimum spike-train length for discriminating noxious from innocuous inputs was 40 ms. The nociceptive coding activity was temporally dynamic, and could be preserved for a relatively long time (3-4 s) within the thalamocortical loops, independent of the initial brief stimuli. These results suggest that the nociceptive signals may be reverberatory within the thalamocortical loops, hence keeping the neurosignature for central pain representation.; Considerable evidence supports that pain is encoded in a large, widespread network that consists of the thalamus, cortex, as well as limbic system. However, the temporal properties of the neural matrix in pain processing were largely unknown. In the present study, we simultaneously recorded thalamic and cortical neuronal discharges elicited by brief noxious or innocuous electrical stimulus in awake rats. The discrimination performance of the neural ensembles in differentiating noxious from innocuous inputs was calculated using different window sizes at the millisecond and second level, respectively. The results demonstrated that coding information emerged in a quantum-like manner; the minimum spike-train length for discriminating noxious from innocuous inputs was 40 ms. The nociceptive coding activity was temporally dynamic, and could be preserved for a relatively long time (3-4 s) within the thalamocortical loops, independent of the initial brief stimuli. These results suggest that the nociceptive signals may be reverberatory within the thalamocortical loops, hence keeping the neurosignature for central pain representation. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
学科主题	认知神经科学
语种	英语
WOS记录号	WOS:000255431500016
公开日期	2011-08-22
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/5730]
专题	心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	F. Luo
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Neurosci Res Inst, Winston Salem, NC USA
推荐引用方式 GB/T 7714	Wang, Jin-Yan,Chang, Jing-Yu,Woodward, Donald J.,et al. Temporal strategy for discriminating noxious from non-noxious electrical stimuli by cortical and thalamic neural ensembles in rats[J]. NEUROSCIENCE LETTERS,2008,435(2):163-168.
APA	Wang, Jin-Yan,Chang, Jing-Yu,Woodward, Donald J.,Luo, Fei,&F. Luo.(2008).Temporal strategy for discriminating noxious from non-noxious electrical stimuli by cortical and thalamic neural ensembles in rats.NEUROSCIENCE LETTERS,435(2),163-168.
MLA	Wang, Jin-Yan,et al."Temporal strategy for discriminating noxious from non-noxious electrical stimuli by cortical and thalamic neural ensembles in rats".NEUROSCIENCE LETTERS 435.2(2008):163-168.

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