Common Genetic Variation and the Control of HIV-1 in Humans

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	Common Genetic Variation and the Control of HIV-1 in Humans
	Fellay, Jacques 1; Ge, Dongliang 1; Shianna, Kevin V.1,2; Colombo, Sara 3; Ledergerber, Bruno 4; Cirulli, Elizabeth T.1; Urban, Thomas J.1; Zhang, Kunlin3,5 ; Gumbs, Curtis E.1; Smith, Jason P.2
刊名	PLOS GENETICS
	2009-12-01
卷号	5 期号:12
关键词	genome-wide association hla-c host genetics infection aids progression disease polymorphism resistance hcp5
ISSN号	1553-7390
文献子类	Article
英文摘要	To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.; To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
学科主题	遗传学
语种	英语
WOS记录号	WOS:000273469700041
公开日期	2011-08-22
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/5260]
专题	心理研究所_中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	D. B. Goldstein
作者单位	1.Duke Univ, Ctr Human Genome Variat, Duke Inst Genome Sci & Policy, Durham, NC 27706 USA 2.Duke Univ, Genom Anal Facil, Duke Inst Genome Sci & Policy, Durham, NC USA 3.Univ Lausanne, Inst Microbiol, Lausanne, Switzerland 4.Univ Zurich, Univ Hosp, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland 5.Chinese Acad Sci, Inst Psychol, Behav Genet Ctr, Beijing 100101, Peoples R China 6.Vita Salute San Raffaele Univ & Diagnost & Ric Sa, Clin Infect Dis, Milan, Italy 7.UCL, Res Dept Infect & Populat Hlth, London, England 8.Univ Cattolica Sacro Cuore, Inst Clin Infect Dis, I-00168 Rome, Italy 9.Kings Coll London, Acad Dept HIV GUM, Weston Educ Ctr, Guys Hosp, London WC2R 2LS, England 10.Kings Coll London, Acad Dept HIV GUM, Weston Educ Ctr, Kings Hosp, London WC2R 2LS, England
推荐引用方式 GB/T 7714	Fellay, Jacques,Ge, Dongliang,Shianna, Kevin V.,et al. Common Genetic Variation and the Control of HIV-1 in Humans[J]. PLOS GENETICS,2009,5(12).
APA	Fellay, Jacques.,Ge, Dongliang.,Shianna, Kevin V..,Colombo, Sara.,Ledergerber, Bruno.,...&D. B. Goldstein.(2009).Common Genetic Variation and the Control of HIV-1 in Humans.PLOS GENETICS,5(12).
MLA	Fellay, Jacques,et al."Common Genetic Variation and the Control of HIV-1 in Humans".PLOS GENETICS 5.12(2009).