Protein-Based 3D Microstructures with Controllable Morphology and pH-Responsive Properties

doi:10.1021/acsami.7b14915

CORC > 重庆绿色智能技术研究院 > 中国科学院重庆绿色智能技术研究院 > 机器人与3D打印技术创新中心

	Protein-Based 3D Microstructures with Controllable Morphology and pH-Responsive Properties
	Wei, Shuxin 1; Liu, Jie 2,3; Zhao, Yuanyuan 4; Zhang, Tingbin 1; Zheng, Meiling 2,3,5; Jin, Feng 2,3; Dong, Xianzi 2,3; Xing, Jinfeng 1; Duan, Xuanming 4
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017-12-06
卷号	9 期号:48 页码:42247-42257
关键词	two-photon polymerization bovine serum albumin 3D microstructure morphology pH response
ISSN号	1944-8244
DOI	10.1021/acsami.7b14915
英文摘要	The microtechnology of controlling stimuli responsive biomaterials at micrometer scale is crucial for biomedical applications. Here, we report bovine serum albumin (BSA)-based three-dimensional (3D) microstructures with tunable surface morphology and pH-responsive properties via two-photon polymerization microfabrication technology. The laser processing parameters, including laser power, scanning speed, and layer distance, are optimized for the fabrication of well-defined 3D BSA microstructures. The tunable morphology of BSA microstructures and a wide range of pH response corresponding to the swelling ratio of 1.08-2.71 have been achieved. The swelling behavior of the microstructures can be strongly influenced by the concentration of BSA precursor, which has been illustrated by a reasonable mechanism. A panda face-shaped BSA microrelief with reversible pH responsive properties is fabricated and exhibits unique "facial expression" variations in pH cycle. We further design a mesh sieve shaped microstructure as a functional device for promising microparticle separation. The pore sizes of microstructures can be tuned by changing the pH values. Therefore, such protein -based microstructures with controllable morphology and pH responsive properties have potential applications especially in biomedicine and biosensors.
资助项目	National Natural Science Foundation of China[31771094] ; National Natural Science Foundation of China[91323301] ; National Natural Science Foundation of China[31371014] ; National Natural Science Foundation of China[61475164] ; Tianjin Science and Technology Innovation Platform Program[14TXGCCX00017] ; National Key Research and Development Program of China[2016YFA0200500] ; National Key Research and Development Program of China[2016YFC1100502] ; Cooperative R&D Projects between Austria, FFG, and China, CAS[GJHZ1720]
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000417669300066
内容类型	期刊论文
源URL	[http://172.16.51.4:88/handle/2HOD01W0/102]
专题	机器人与3D打印技术创新中心
通讯作者	Zheng, Meiling; Xing, Jinfeng; Duan, Xuanming
作者单位	1.Tianjin Univ, Sch Chem Engn & Technol, 135 Yaguan Rd,Haihe Educ Pk, Tianjin 300350, Peoples R China 2.Chinese Acad Sci, Lab Organ NanoPhoton, 29 Zhongguancun East Rd, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Key Lab Bioinspired Mat & Interfacial Sci, Tech Inst Phys & Chem, 29 Zhongguancun East Rd, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Shuitu Technol Dev Zone, 266 Fangzheng Ave, Chongqing 400714, Peoples R China 5.Univ Chinese Acad Sci, Sch Future Technol, Yanqihu Campus, Beijing 101407, Peoples R China
推荐引用方式 GB/T 7714	Wei, Shuxin,Liu, Jie,Zhao, Yuanyuan,et al. Protein-Based 3D Microstructures with Controllable Morphology and pH-Responsive Properties[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(48):42247-42257.
APA	Wei, Shuxin.,Liu, Jie.,Zhao, Yuanyuan.,Zhang, Tingbin.,Zheng, Meiling.,...&Duan, Xuanming.(2017).Protein-Based 3D Microstructures with Controllable Morphology and pH-Responsive Properties.ACS APPLIED MATERIALS & INTERFACES,9(48),42247-42257.
MLA	Wei, Shuxin,et al."Protein-Based 3D Microstructures with Controllable Morphology and pH-Responsive Properties".ACS APPLIED MATERIALS & INTERFACES 9.48(2017):42247-42257.