Synthesis of 5-subsituted flavonols via the Algar-Flynn-Oyamada (AFO) reaction: The mechanistic implication

doi:10.1016/j.tet.2017.06.064

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	Synthesis of 5-subsituted flavonols via the Algar-Flynn-Oyamada (AFO) reaction: The mechanistic implication
	Shen, Xianyan 1,2; Zhou, Qiang 1; Xiong, Wei 1,2; Pu, Wenchen 1; Zhang, Wei3 ; Zhang, Guolin 1; Wang, Chun 1
刊名	TETRAHEDRON
	2017-08-10
卷号	73 期号:32 页码:4822-4829
关键词	Flavonol Synthesis Afo Mechanism
ISSN号	0040-4020
DOI	10.1016/j.tet.2017.06.064
英文摘要	Herein, we report a synthetic method with improved selectivity for 5-substituted flavonols via the Algar-Flynn-Oyamada reaction (AFO), by using of sodium carbonate/hydrogen peroxide A series of 5 substituted flavonols was obtained with moderate to high yields. The mechanism of the AFO reaction was elucidated. LCMS analysis and in situ H-1 NMR analysis indicated that the epoxide was involved in the transformation from chalcone to flavonol and/or aurone under alkaline base/peroxide conditions. (C) 2017 Elsevier Ltd. All rights reserved.
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000406736100015
内容类型	期刊论文
源URL	[http://172.16.51.4:88/handle/2HOD01W0/175]
专题	科研公共服务平台
作者单位	1.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China
推荐引用方式 GB/T 7714	Shen, Xianyan,Zhou, Qiang,Xiong, Wei,et al. Synthesis of 5-subsituted flavonols via the Algar-Flynn-Oyamada (AFO) reaction: The mechanistic implication[J]. TETRAHEDRON,2017,73(32):4822-4829.
APA	Shen, Xianyan.,Zhou, Qiang.,Xiong, Wei.,Pu, Wenchen.,Zhang, Wei.,...&Wang, Chun.(2017).Synthesis of 5-subsituted flavonols via the Algar-Flynn-Oyamada (AFO) reaction: The mechanistic implication.TETRAHEDRON,73(32),4822-4829.
MLA	Shen, Xianyan,et al."Synthesis of 5-subsituted flavonols via the Algar-Flynn-Oyamada (AFO) reaction: The mechanistic implication".TETRAHEDRON 73.32(2017):4822-4829.