Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室 > 污染过程与控制实验室

	Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway
	Zhou, Hailong 1,2,3,4; Wu, Huifeng1 ; Liao, Chunyang1 ; Diao, Xiaoping 2; Zhen, Jiping 2; Chen, Linlin1 ; Xue, Qinzhao1
刊名	TOXICOLOGY MECHANISMS AND METHODS
	2010-07-01
卷号	20 期号:6 页码:279-286
关键词	Persistent Organic Pollutants Ahr Pathway Toxicology Mechanism Fish
ISSN号	1537-6524
通讯作者	Xue, QZ, Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
产权排序	[Zhou, Hailong; Wu, Huifeng; Liao, Chunyang; Chen, Linlin; Xue, Qinzhao] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Zhou, Hailong; Diao, Xiaoping; Zhen, Jiping] Hainan Univ, Dept Biotechnol, Coll Agr, Haikou 570228, Peoples R China; [Zhou, Hailong] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; [Zhou, Hailong] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
文献子类	Review
英文摘要	With the development of industry and agriculture, the cases of cancer and tumor have been increasing gradually in the last 30 years, and quite a few cases are caused by persistent organic pollutants (POPs), some of them belonging to environmental endocrine disruptors, and they have become ubiquitous in the environment, especially in the aquatic ecosystem; so this issue has aroused the extensive attention of the world. The mechanism of POPs toxicology is very complicated, but it is mainly mediated by the aryl hydrocarbon receptor (AhR) pathway in fish. In order to gain a comprehensive understanding of the AhR pathway, the present paper focuses on reviewing it from four major steps, including formation of cytosolic complex, translocation of AhR, heterodimerization of AhR, and induction of CYP1A. This study summarized the isoform numbers of AhR pathway genes and the expression patterns in the regulation process of POPs toxicology in zebrafish.; With the development of industry and agriculture, the cases of cancer and tumor have been increasing gradually in the last 30 years, and quite a few cases are caused by persistent organic pollutants (POPs), some of them belonging to environmental endocrine disruptors, and they have become ubiquitous in the environment, especially in the aquatic ecosystem; so this issue has aroused the extensive attention of the world. The mechanism of POPs toxicology is very complicated, but it is mainly mediated by the aryl hydrocarbon receptor (AhR) pathway in fish. In order to gain a comprehensive understanding of the AhR pathway, the present paper focuses on reviewing it from four major steps, including formation of cytosolic complex, translocation of AhR, heterodimerization of AhR, and induction of CYP1A. This study summarized the isoform numbers of AhR pathway genes and the expression patterns in the regulation process of POPs toxicology in zebrafish.
学科主题	Toxicology
URL标识	查看原文
WOS关键词	ARYL-HYDROCARBON RECEPTOR ; HEAT-SHOCK-PROTEIN ; NUCLEAR-LOCALIZATION SIGNAL ; POLYCYCLIC AROMATIC-HYDROCARBONS ; X-ASSOCIATED PROTEIN-2 ; ZEBRAFISH DANIO-RERIO ; CO-CHAPERONE P23 ; DIOXIN RECEPTOR ; DNA-BINDING ; NUCLEOCYTOPLASMIC TRANSPORT
WOS研究方向	Toxicology
语种	英语
WOS记录号	WOS:000280402000001
资助机构	Chinese Academy of Sciences [KZCX2-YW-Q07-05, KZCX2-YW-Q07-04]; Yantai municipal Science and technology development program [2007323]; Science and technology bureau of Yantai city [2009164]; Natural Science Foundation of Hainan Province [309010]; Education Department of Hainan Province [Hj2009-21]
公开日期	2011-07-14
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/3802]
专题	烟台海岸带研究所_污染过程与控制实验室烟台海岸带研究所_中科院烟台海岸带研究所知识产出
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Hainan Univ, Dept Biotechnol, Coll Agr, Haikou 570228, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Hailong,Wu, Huifeng,Liao, Chunyang,et al. Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway[J]. TOXICOLOGY MECHANISMS AND METHODS,2010,20(6):279-286.
APA	Zhou, Hailong.,Wu, Huifeng.,Liao, Chunyang.,Diao, Xiaoping.,Zhen, Jiping.,...&Xue, Qinzhao.(2010).Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway.TOXICOLOGY MECHANISMS AND METHODS,20(6),279-286.
MLA	Zhou, Hailong,et al."Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway".TOXICOLOGY MECHANISMS AND METHODS 20.6(2010):279-286.