Synthesis and characterization of self-assembled CdHgTe/gelatin nanospheres as stable near infrared fluorescent probes in vivo

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室 > 环境化学实验室

	Synthesis and characterization of self-assembled CdHgTe/gelatin nanospheres as stable near infrared fluorescent probes in vivo
	Wang, Yunqing1,2,3 ; Ye, Chao 1,2; Wu, Liheng 1,2; Hu, Yuzhu 1,2
刊名	JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
	2010-11-02
卷号	53 期号:3 页码:235-242
关键词	Cdhgte/gelatin Nanospheres Biomimetic Synthesis Fluorescent Probes Near Infrared Imaging In Vivo Visible Drug Nanocarriers
ISSN号	0731-7085
通讯作者	Hu, YZ, Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China
产权排序	[Wang, Yunqing; Ye, Chao; Wu, Liheng; Hu, Yuzhu] Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China; [Wang, Yunqing; Ye, Chao; Wu, Liheng; Hu, Yuzhu] China Pharmaceut Univ, Dept Analyt Chem, Nanjing 210009, Peoples R China; [Wang, Yunqing] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
文献子类	Article
英文摘要	This work presented a kind of novel near infrared emitting CdHgTe/gelatin nanospheres which were synthesized with Cd(NO3)(2), Hg(NO3)(2). NaHTe and a thiol stabilizer in gelatin solution The self-assembled nanospheres were megranate-like and nearly 40 nm in diameter, with CdHgTe QDs uniformly embedded in gelatin matrix. They exhibited strong fluorescence ranging from 580 to 800 nm that could be tuned by molar ratios of Hg2+ and gelatin. The full widths at half-maximum of the emission spectra were in the range of 60-80 nm. Compared with bare CdHgTe QDs, the photostability of this compact complex nanostructure remarkably improved. Moreover, the fluorescence of CdHgTe/gelatin nanospheres was much more resistant to the interference from certain kinds of endogenous biomolecules such as HSA, transferrin and hemoglobin Further applications of living cells and mouse imaging were demonstrated with an in vivo near infrared fluorescence imaging system The Inherent advantages of high stability as well as high fluorescence intensity make the nanospheres particular interested NIR bioprobe candidates for in vivo imaging studies (C) 2010 Elsevier B.V. All rights reserved; This work presented a kind of novel near infrared emitting CdHgTe/gelatin nanospheres which were synthesized with Cd(NO(3))(2), Hg(NO(3))(2). NaHTe and a thiol stabilizer in gelatin solution The self-assembled nanospheres were megranate-like and nearly 40 nm in diameter, with CdHgTe QDs uniformly embedded in gelatin matrix. They exhibited strong fluorescence ranging from 580 to 800 nm that could be tuned by molar ratios of Hg(2+) and gelatin. The full widths at half-maximum of the emission spectra were in the range of 60-80 nm. Compared with bare CdHgTe QDs, the photostability of this compact complex nanostructure remarkably improved. Moreover, the fluorescence of CdHgTe/gelatin nanospheres was much more resistant to the interference from certain kinds of endogenous biomolecules such as HSA, transferrin and hemoglobin Further applications of living cells and mouse imaging were demonstrated with an in vivo near infrared fluorescence imaging system The Inherent advantages of high stability as well as high fluorescence intensity make the nanospheres particular interested NIR bioprobe candidates for in vivo imaging studies (C) 2010 Elsevier B.V. All rights reserved
学科主题	Chemistry, Analytical ; Pharmacology & Pharmacy
URL标识	查看原文
WOS关键词	QUANTUM DOTS ; MOUSE MODEL ; NANOPARTICLES ; GROWTH
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000280435800003
公开日期	2011-07-14
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/3732]
专题	烟台海岸带研究所_环境化学实验室
作者单位	1.Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China 2.China Pharmaceut Univ, Dept Analyt Chem, Nanjing 210009, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yunqing,Ye, Chao,Wu, Liheng,et al. Synthesis and characterization of self-assembled CdHgTe/gelatin nanospheres as stable near infrared fluorescent probes in vivo[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2010,53(3):235-242.
APA	Wang, Yunqing,Ye, Chao,Wu, Liheng,&Hu, Yuzhu.(2010).Synthesis and characterization of self-assembled CdHgTe/gelatin nanospheres as stable near infrared fluorescent probes in vivo.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,53(3),235-242.
MLA	Wang, Yunqing,et al."Synthesis and characterization of self-assembled CdHgTe/gelatin nanospheres as stable near infrared fluorescent probes in vivo".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 53.3(2010):235-242.