Molecular fluorescent probes for monitoring pH changes in living cells

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 山东省海岸带环境工程技术研究中心

	Molecular fluorescent probes for monitoring pH changes in living cells
	Wang, Rui 1; Yu, Chunwei 1,2; Yu, Fabiao 1; Chen, Lingxin1
刊名	TRAC-TRENDS IN ANALYTICAL CHEMISTRY
	2010-10-01
卷号	29 期号:9 页码:1004-1013
关键词	Fluorescence Microscopy Fluorescent Probe Intracellular Ph Living Cell Organic Synthesis Ph Detection Ph Indicator Ph Regulation Signal Transduction Small Molecular Probe
ISSN号	0165-9936
通讯作者	Chen, LX, Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
产权排序	[Wang, Rui; Yu, Chunwei; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Yu, Chunwei] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
文献子类	Review
英文摘要	The availability of synthetic fluorescent probes and the development of powerful new approaches to microscopy have made fluorescence microscopy an essential tool for biomedical science and biology. Intracellular pH plays vital roles in physiological and pathological processes (e.g., receptor-mediated signal transduction, cell growth and apoptosis, ion transport, and homeostasis). Due to the presence of an H+ acceptor linked to the fluorophore, some small molecular fluorescent probes display pH-sensitive absorption and fluorescence emission. Such behavior has been employed to engineer pH indicators for studies of pH regulation in vivo. The review summarizes advances in the creation of novel molecular fluorescent pH probes and their applications in biomedicine and cell biology, especially focusing on the design and the synthesis of small molecular probes for monitoring pH changes in living cells. (C) 2010 Elsevier Ltd. All rights reserved.; The availability of synthetic fluorescent probes and the development of powerful new approaches to microscopy have made fluorescence microscopy an essential tool for biomedical science and biology. Intracellular pH plays vital roles in physiological and pathological processes (e.g., receptor-mediated signal transduction, cell growth and apoptosis, ion transport, and homeostasis). Due to the presence of an H+ acceptor linked to the fluorophore, some small molecular fluorescent probes display pH-sensitive absorption and fluorescence emission. Such behavior has been employed to engineer pH indicators for studies of pH regulation in vivo. The review summarizes advances in the creation of novel molecular fluorescent pH probes and their applications in biomedicine and cell biology, especially focusing on the design and the synthesis of small molecular probes for monitoring pH changes in living cells. (C) 2010 Elsevier Ltd. All rights reserved.
学科主题	Chemistry, Analytical
URL标识	查看原文
WOS关键词	AQUEOUS-SOLUTIONS ; INTRACELLULAR PH ; HEPG2 CELLS ; SENSORS ; ACIDIFICATION ; DERIVATIVES ; DYES ; CA2+ ; EXCITATION ; INHIBITION
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000282542800014
资助机构	Department of Science and Technology of Shandong Province of China [2008GG20005005]; National Natural Science Foundation of China [20975089]; Natural Science Foundation of Shandong Province of China [Y2007B38]; Chinese Academy of Sciences
公开日期	2011-07-14
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/3720]
专题	烟台海岸带研究所_山东省海岸带环境工程技术研究中心
作者单位	1.Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Rui,Yu, Chunwei,Yu, Fabiao,et al. Molecular fluorescent probes for monitoring pH changes in living cells[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2010,29(9):1004-1013.
APA	Wang, Rui,Yu, Chunwei,Yu, Fabiao,&Chen, Lingxin.(2010).Molecular fluorescent probes for monitoring pH changes in living cells.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,29(9),1004-1013.
MLA	Wang, Rui,et al."Molecular fluorescent probes for monitoring pH changes in living cells".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 29.9(2010):1004-1013.