Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells

doi:10.1016/j.chemosphere.2017.08.083

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	Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells
	Li, Fei1 ; Wang, Li 3,4; Ji, Chenglong1 ; Wu, Huifeng1,2 ; Zhao, Jianmin1 ; Tang, Jianhui1 ; Wu, Huifeng(Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China)
刊名	CHEMOSPHERE
	2017-11-01
卷号	187 页码:88-96
关键词	Tris(2-chloropropyl) Phosphate (Tcpp) L02 Cells Cell Apoptosis Ros Metabolomics Proteomics
ISSN号	0045-6535
DOI	10.1016/j.chemosphere.2017.08.083
产权排序	第1完成单位
文献子类	Article
英文摘要	Organophosphate flame retardants (OPFRs) are widely used as flame retardants which are ubiquitous in various environment media. As many of OPFRs are toxic and persistent, concerns have been raised in regards to their environmental impact. In this study, the toxicological effects of tris(2-chloropropyl) phosphate (TCPP) in human L02 cells was investigated by cell proliferation and apoptosis, oxidative stress, metabolomic and proteomic responses as well as gene expressions related to apoptosis. Results showed that TCPP did not significantly affect the L02 cell apoptosis, however, a significant increase of ROS production was observed in L02 cells with TCPP treatment compared with that in control group (p < 0.05). The expression levels of Bcl-2 family-encoding genes (Bax, Hrk and Bax/Bcl-2) were up regulated significantly in 10(-4) M group (p < 0.05). Metabolomic and proteomic responses indicated that TCPP mainly caused disturbance in cell growth/division and gene expression, energy and material metabolism, signal transduction, defense and cytoskeleton, which was further confirmed by the western blot analysis. (C) 2017 Elsevier Ltd. All rights reserved.
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WOS关键词	ORGANOPHOSPHORUS FLAME RETARDANTS ; LASER-DESORPTION/IONIZATION-TIME ; IN-VITRO ; PROTEIN EXPRESSION ; GENE-EXPRESSION ; SURFACE WATERS ; PLASTICIZERS ; METABOLOMICS ; PROTEOMICS ; TOXICITY
WOS研究方向	Environmental Sciences & Ecology
语种	英语
WOS记录号	WOS:000412618900011
资助机构	National Natural Science Foundation of China(41530642, 21677173) ; Youth Innovation Promotion Association CAS(2017255) ; Chinese Academy of Sciences(KZZD-EW-14, XDA11020305)
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/23459]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者	Wu, Huifeng; Wu, Huifeng(Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China)
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Zone Environm Proc & Ecol Remedia, Yantai 264003, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China 3.Yantai Yuhuangding Hosp, Dept Integrated Tradit, Yuhuangdingdong Rd 20, Yantai 264000, Shandong, Peoples R China 4.Yantai Yuhuangding Hosp, Dept Western Med, Yuhuangdingdong Rd 20, Yantai 264000, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Li, Fei,Wang, Li,Ji, Chenglong,et al. Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells[J]. CHEMOSPHERE,2017,187:88-96.
APA	Li, Fei.,Wang, Li.,Ji, Chenglong.,Wu, Huifeng.,Zhao, Jianmin.,...&Wu, Huifeng.(2017).Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells.CHEMOSPHERE,187,88-96.
MLA	Li, Fei,et al."Toxicological effects of tris(2-chloropropyl) phosphate in human hepatic cells".CHEMOSPHERE 187(2017):88-96.