Nitrobenzoyl Sesquiterpenoids with Cytotoxic Activities from a Marine-Derived Aspergillus ochraceus Fungus

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	Nitrobenzoyl Sesquiterpenoids with Cytotoxic Activities from a Marine-Derived Aspergillus ochraceus Fungus
	Tan, YH; Yang, B; Lin, XP; Luo, XW; Pang, XY; Tang, L; Liu, YH; Li, XJ; Zhou, XF
刊名	JOURNAL OF NATURAL PRODUCTS
	2018
卷号	81 期号:1 页码:92-97
通讯作者	lixiaoj@smu.edu.cn
英文摘要	Nitrobenzoyl sesquiterpenoids are rare from natural sources. Two new nitrobenzoyl sesquiterpenoids, insulicolide B (1) and insulicolide C (3), and the new natural product 14-O-acetylinsulicolide A (2) were isolated from culture extracts of the marine-derived fungus Aspergillus ochraceus JcmalF17, together with three known nitrobenzoyl sesquiterpenoids (4-6) and a derivative sesquiterpenoid (7). The structures of the new compounds, including their absolute configurations, were determined by NMR. and MS spectroscopic data analyses and comparison between the calculated and experimental ECD spectra. The nitrobenzoyl sesquiterpenoids (1-6) were evaluated for their cytotoxicities against three renal carcinoma cell lines, ACHN, OS-RC-2, and 786-O cells, and compounds 2, 4, and 5 displayed activities with IC50 values of 0.89 to 8.2 mu M. Further studies indicated that 2 arrested the cell cycle at the G0/G1 phase at a concentration of 1 mu M and induced late apoptosis at a concentration of 2 mu M after a 72 h treatment of 786-O cells.
学科主题	Plant Sciences; Pharmacology & Pharmacy
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17033]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Tan, YH,Yang, B,Lin, XP,et al. Nitrobenzoyl Sesquiterpenoids with Cytotoxic Activities from a Marine-Derived Aspergillus ochraceus Fungus[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(1):92-97.
APA	Tan, YH.,Yang, B.,Lin, XP.,Luo, XW.,Pang, XY.,...&Zhou, XF.(2018).Nitrobenzoyl Sesquiterpenoids with Cytotoxic Activities from a Marine-Derived Aspergillus ochraceus Fungus.JOURNAL OF NATURAL PRODUCTS,81(1),92-97.
MLA	Tan, YH,et al."Nitrobenzoyl Sesquiterpenoids with Cytotoxic Activities from a Marine-Derived Aspergillus ochraceus Fungus".JOURNAL OF NATURAL PRODUCTS 81.1(2018):92-97.