Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations
	Sun, CL; Zhang, CY; Qin, XJ; Wei, XY; Liu, Q; Li, QL; Ju, JH
刊名	TETRAHEDRON
	2018
卷号	74 期号:1 页码:199-203
通讯作者	jju@scsio.ac.cn
英文摘要	Naphthoquinone macrolides have attracted considerable synthetic interest due to their unique scaffolds, but there was no completion of total synthesis reported. In this study, genome mining and genetic manipulations were applied to stimulate the production of naphthoquinone macrolides from the deep-sea actinomycete Streptomyces olivaceus SCSIO T05; as a result, new metabolites olimycins A and B (1, 2) were isolated. The structures were elucidated on the basis of extensive spectroscopic data and X-ray single crystal diffraction studies. The results of these efforts enabled rectification of a key structural error made during previous efforts to characterize naphthoquinone macrolides. (C) 2017 Elsevier Ltd. All rights reserved.
学科主题	Chemistry
关键词[WOS]	Genome mining ; Naphthoquinone macrolides ; Absolute configuration ; Structure rectification
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17018]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Sun, CL,Zhang, CY,Qin, XJ,et al. Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations[J]. TETRAHEDRON,2018,74(1):199-203.
APA	Sun, CL.,Zhang, CY.,Qin, XJ.,Wei, XY.,Liu, Q.,...&Ju, JH.(2018).Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations.TETRAHEDRON,74(1),199-203.
MLA	Sun, CL,et al."Genome mining of Streptomyces olivaceus SCSIO T05: Discovery of olimycins A and B and assignment of absolute configurations".TETRAHEDRON 74.1(2018):199-203.