Grincamycins I-K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Grincamycins I-K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32
	Lai, ZZ; Yu, JC; Ling, HP; Song, YX; Yuan, J; Ju, JH; Tao, YW; Huang, HB
刊名	PLANTA MEDICA
	2018
卷号	84 期号:3 页码:201-207
通讯作者	yywentao@aliyun.com ; huanghb@scsio.ac.cn
英文摘要	Three new angucycline glycosides, designated grincamycin I ( 1 ), J ( 2 ), and K ( 3 ), together with the known congener A-7884 ( 4 ), were isolated from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. The structures of the new compounds were elucidated by comprehensive spectral data analysis. Compounds 2 and 4 exhibited antitumor activity against human cancer cells MDA-MB-435, MDA-MB-231, NCI-H460, HCT-116 and HepG2, and human normal breast epithelial cell MCF10A with IC (50) values ranging from 0.4 to 6.9 mu M. In addition, A-7884 ( 4 ) demonstrated antimicrobial activity against Micrococcus luteus with an MIC value of 1.95 mu g/mL.
学科主题	Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine
关键词[WOS]	angucycline glycoside ; naphthacenequinone ; cytotoxicity ; marine actinomycete ; Streptomyces lusitanus ; Streptomycetaceae
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/17011]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Lai, ZZ,Yu, JC,Ling, HP,et al. Grincamycins I-K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32[J]. PLANTA MEDICA,2018,84(3):201-207.
APA	Lai, ZZ.,Yu, JC.,Ling, HP.,Song, YX.,Yuan, J.,...&Huang, HB.(2018).Grincamycins I-K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32.PLANTA MEDICA,84(3),201-207.
MLA	Lai, ZZ,et al."Grincamycins I-K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32".PLANTA MEDICA 84.3(2018):201-207.