New chlorinated diphenyl ethers and xanthones from a deep-sea-derived I fungus Penicillium chrysogenum SCSIO 41001

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	New chlorinated diphenyl ethers and xanthones from a deep-sea-derived I fungus Penicillium chrysogenum SCSIO 41001
	Wang, JF; Zhou, LM; Chen, ST; Yang, B; Liao, SR; Kong, FD; Lin, XP; Wang, FZ; Zhou, XF; Liu, YH
刊名	FITOTERAPIA
	2018
卷号	125 页码:49-54
英文摘要	Seven new compounds, including four new chlorinated diphenyl ethers, namely chrysines A-D (1-4), one new dichlorinated xanthone, chrysoxanthone (5), dichloroorcinol (6), and one new benzeneacetic acid derivative, 3-isopentyl-4-hydroxy phenylacetic acid methyl ester (7), along with fourteen known compounds (8-21), were isolated from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001. Their structures were determined by extensive spectroscopic methods and X-ray single-crystal diffraction analysis. All of the isolated compounds (1 - 21) were evaluated for their a-glucosidase inhibitory activity using PNPG method. Among them, nine compounds (2, 3, 5, 6, 8, 9, 13, 17, and 18) exhibited inhibitory activity against alpha-glucosidase with IC50 values of 0.35, 0.20, 0.04, 0.16, 0.15, 0.09, 0.14, 0.14, and 0.12 mM, respectively (IC50 0.28 mM for the positive control acarbose).
学科主题	Pharmacology & Pharmacy
资助项目	LMB
WOS关键词	Penicillium chrysogenum ; Diphenyl ether ; Xanthone ; alpha-Glucosidase inhibitory activity
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/16995]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
通讯作者	wangjunfeng@scsio.ac.cn; yonghongliu@scsio.ac.cn
推荐引用方式 GB/T 7714	Wang, JF,Zhou, LM,Chen, ST,et al. New chlorinated diphenyl ethers and xanthones from a deep-sea-derived I fungus Penicillium chrysogenum SCSIO 41001[J]. FITOTERAPIA,2018,125:49-54.
APA	Wang, JF.,Zhou, LM.,Chen, ST.,Yang, B.,Liao, SR.,...&yonghongliu@scsio.ac.cn.(2018).New chlorinated diphenyl ethers and xanthones from a deep-sea-derived I fungus Penicillium chrysogenum SCSIO 41001.FITOTERAPIA,125,49-54.
MLA	Wang, JF,et al."New chlorinated diphenyl ethers and xanthones from a deep-sea-derived I fungus Penicillium chrysogenum SCSIO 41001".FITOTERAPIA 125(2018):49-54.