Protective Effects of Enteral Nutrition Supplemented with Crassostrea hongkongensis Polysaccharides Against 5-Fluorouracil-Induced Intestinal Mucosal Damage in Rats

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	Protective Effects of Enteral Nutrition Supplemented with Crassostrea hongkongensis Polysaccharides Against 5-Fluorouracil-Induced Intestinal Mucosal Damage in Rats
	Cai, BN; Wan, P; Sun, HL; Chen, DK; Chen, H; Chen, X; Pan, JY
刊名	JOURNAL OF MEDICINAL FOOD
	2018
卷号	21 期号:4 页码:348-355
通讯作者	jypan@scsio.ac.cn
英文摘要	Chemotherapeutics, including 5-fluorouracil (5-FU), often damage the intestinal mucosal barrier and cause intestinal mucositis (IM). Supplementation with immunoregulatory polysaccharides from Crassostrea hongkongensis has been shown to positively influence the effectiveness and toxicity of 5-FU. Therefore, we studied the effects of oyster polysaccharides on 5-FU-induced intestinal mucosal damage in rats. The C30-60% ethanol-precipitated fraction of polysaccharides promoted IEC-6 cell proliferation and exhibited a maximal effect at a 0.0195 mg/mL concentration. Moreover, treatment with C30-60% polysaccharide-based nutrition formula (OPNF) partially prevented the 5-FU-induced degenerative changes in the histology and ultrastructure of small intestinal mucosa. In addition, the endotoxin level of rats fed with 5-FU and OPNF decreased to the normal control level. Furthermore, the 5-FU-induced increase of proinflammatory cytokine interleukin (IL)-2 and the decrease of anti-inflammatory cytokine IL-10 level in the peripheral blood were significantly attenuated by OPNF administration. In conclusion, Oyster C30-60% polysaccharides can ameliorate 5-FU-induced IM by partially preventing mucosal damage, reducing inflammation, and promoting immunity.
学科主题	Pharmacology & Pharmacy; Food Science & Technology; Nutrition & Dietetics
关键词[WOS]	Crassostrea hongkongensis ; cytokine ; enteral nutrition ; intestinal mucosa ; polysaccharide
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/16982]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Cai, BN,Wan, P,Sun, HL,et al. Protective Effects of Enteral Nutrition Supplemented with Crassostrea hongkongensis Polysaccharides Against 5-Fluorouracil-Induced Intestinal Mucosal Damage in Rats[J]. JOURNAL OF MEDICINAL FOOD,2018,21(4):348-355.
APA	Cai, BN.,Wan, P.,Sun, HL.,Chen, DK.,Chen, H.,...&Pan, JY.(2018).Protective Effects of Enteral Nutrition Supplemented with Crassostrea hongkongensis Polysaccharides Against 5-Fluorouracil-Induced Intestinal Mucosal Damage in Rats.JOURNAL OF MEDICINAL FOOD,21(4),348-355.
MLA	Cai, BN,et al."Protective Effects of Enteral Nutrition Supplemented with Crassostrea hongkongensis Polysaccharides Against 5-Fluorouracil-Induced Intestinal Mucosal Damage in Rats".JOURNAL OF MEDICINAL FOOD 21.4(2018):348-355.