Antimalarial Activity of Plant Metabolites

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	Antimalarial Activity of Plant Metabolites
	Zhang, HJ; Xu, XY; Shi, N; Pan, WH; Tsang, SW
刊名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
	2018
卷号	19 期号:5 页码:-1382
通讯作者	13480448@life.hkbu.edu.hk ; xuxinya@scsio.ac.cn ; 14252252@life.hkbu.edu.hk ; tsang@hkbu.edu.hk ; zhanghj@hkbu.edu.hk
英文摘要	Malaria, as a major global health problem, continues to affect a large number of people each year, especially those in developing countries. Effective drug discovery is still one of the main efforts to control malaria. As natural products are still considered as a key source for discovery and development of therapeutic agents, we have evaluated more than 2000 plant extracts against Plasmodium falciparum. As a result, we discovered dozens of plant leads that displayed antimalarial activity. Our phytochemical study of some of these plant extracts led to the identification of several potent antimalarial compounds. The prior comprehensive review article entitled Antimalarial activity of plant metabolites by Schwikkard and Van Heerden (2002) reported structures of plant-derived compounds with antiplasmodial activity and covered literature up to the year 2000. As a continuation of this effort, the present review covers the antimalarial compounds isolated from plants, including marine plants, reported in the literature from 2001 to the end of 2017. During the span of the last 17 years, 175 antiplasmodial compounds were discovered from plants. These active compounds are organized in our review article according to their plant families. In addition, we also include ethnobotanical information of the antimalarial plants discussed.
学科主题	Biochemistry & Molecular Biology; Chemistry
关键词[WOS]	anti-malaria activity ; plants ; natural products ; ethnopharmacology ; Plasmodium parasites
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/16950]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Zhang, HJ,Xu, XY,Shi, N,et al. Antimalarial Activity of Plant Metabolites[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018,19(5):-1382.
APA	Zhang, HJ,Xu, XY,Shi, N,Pan, WH,&Tsang, SW.(2018).Antimalarial Activity of Plant Metabolites.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,19(5),-1382.
MLA	Zhang, HJ,et al."Antimalarial Activity of Plant Metabolites".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19.5(2018):-1382.