Tandem Hydration of Diisonitriles Triggered by Isonitrile Hydratase in Streptomyces thioluteus

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	Tandem Hydration of Diisonitriles Triggered by Isonitrile Hydratase in Streptomyces thioluteus
	Zhang, QB; He, J; Zhu, YG; Zhang, HB; Gu, XF; Yu, PQ; Zhu, SQ; Ali, M; Wang, LJ; Zhu, MY
刊名	ORGANIC LETTERS
	2018
卷号	20 期号:12 页码:3562-3565
通讯作者	hejingjj@mail.hzau.edu
英文摘要	The biosynthetic pathway of diisonitrile chalkophore SF2768 was identified in Streptomyces thioluteus through heterologous expression recently. Isolation and structure elucidation of the N-substituted formamides that coexisted with the diisonitriles implied that a hydration event was involved. In vitro enzymatic assays of an endogenous isonitrile hydratase suggested a rare sequential-hydration of the diisonitriles. Additionally, the results of Cu-CAS assays indicate that both partial and complete hydration led to the loss of the copper-chelating ability of SF2768.
学科主题	Chemistry
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/16928]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Zhang, QB,He, J,Zhu, YG,et al. Tandem Hydration of Diisonitriles Triggered by Isonitrile Hydratase in Streptomyces thioluteus[J]. ORGANIC LETTERS,2018,20(12):3562-3565.
APA	Zhang, QB.,He, J.,Zhu, YG.,Zhang, HB.,Gu, XF.,...&Zhu, MY.(2018).Tandem Hydration of Diisonitriles Triggered by Isonitrile Hydratase in Streptomyces thioluteus.ORGANIC LETTERS,20(12),3562-3565.
MLA	Zhang, QB,et al."Tandem Hydration of Diisonitriles Triggered by Isonitrile Hydratase in Streptomyces thioluteus".ORGANIC LETTERS 20.12(2018):3562-3565.