A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging | |
Cui, X. X.1; Fan, Q.1,2; Shi, S. J.3; Wen, W. H.4; Chen, D. F.5; Guo, H. T.1; Xu, Y. T.1; Gao, F.1; Nie, R. Z.1; Ford, Harold D.6 | |
刊名 | NANOTECHNOLOGY
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2018-05-18 | |
卷号 | 29期号:20 |
关键词 | Nanomaterials Biomaterials Medical Optics And Biotechnology Fluorescence Microscopy Spectroscopy Fluorescence And Luminescence |
ISSN号 | 0957-4484 |
DOI | 10.1088/1361-6528/aab2fa |
产权排序 | 1 |
文献子类 | Article |
英文摘要 | Fluorescence imaging signal is severely limited by the quantum efficiency and emission wavelength. To overcome these challenges, novel NIR-emitting K5NdLi2F10 nanoparticles under NIR excitation was introduced as fluorescence imaging probe for the first time. The photostability of K5NdLi2F10 nanoparticles in the water, phosphate buffer saline, fetal bovine serum and living mice was investigated. The fluorescence signal was detected with depths of 3.5 and 2.0 cm in phantom and pork tissue, respectively. Fluorescence spectrum with a significant signal-to-background ratio of 10:1 was captured in living mice. Moreover, clear NIR images were virtualized for the living mice after intravenous injection. The imaging ability of nanoparticles in tumor-beard mice were evaluated, the enrichment of K5NdLi2F10 nanoparticles in tumor site due to the enhanced permeability and retention effect was confirmed. The systematic studies of toxicity, bio-distribution and in-vivo dynamic imaging suggest that these materials give high biocompatibility and low toxicity. These NIR-emitting nanoparticles with high quantum efficiency, high penetration and low toxicity might facilitate tumor identification in deep tissues more sensitively. |
学科主题 | Nanoscience & Nanotechnology |
WOS关键词 | 2nd Biological Window ; Carbon Nanotubes ; Long Lifetime ; Dots ; Fluorescence ; Nanoparticles ; Nanocrystals ; Diagnostics ; K5ndli2f10 |
WOS研究方向 | Science & Technology - Other Topics ; Materials Science ; Physics |
语种 | 英语 |
WOS记录号 | WOS:000428270900002 |
资助机构 | National Natural Science Foundation of China(61107015 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ8345) ; 61205039 ; 61475189) |
内容类型 | 期刊论文 |
源URL | [http://ir.opt.ac.cn/handle/181661/30021] ![]() |
专题 | 西安光学精密机械研究所_先进光电与生物材料研发中心 |
通讯作者 | Peng, B (reprint author), Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Xian 710119, Shaanxi, Peoples R China. |
作者单位 | 1.Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Xian 710119, Shaanxi, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Fourth Millitary Med Univ, Xijing Hosp, Dept Urol, Xian 710032, Shaanxi, Peoples R China 4.Fourth Millitary Med Univ, Dept Immunol, State Key Lab Canc Biol, Xian 710069, Shaanxi, Peoples R China 5.Xi Dian Univ, Sch Life Sci & Biotechnol, Xian 710126, Shaanxi, Peoples R China 6.PTA Tech Inc, 315-515 West Pender St, Vancouver, BC V6B 6H5, Canada |
推荐引用方式 GB/T 7714 | Cui, X. X.,Fan, Q.,Shi, S. J.,et al. A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging[J]. NANOTECHNOLOGY,2018,29(20). |
APA | Cui, X. X..,Fan, Q..,Shi, S. J..,Wen, W. H..,Chen, D. F..,...&Peng, B .(2018).A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging.NANOTECHNOLOGY,29(20). |
MLA | Cui, X. X.,et al."A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging".NANOTECHNOLOGY 29.20(2018). |
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