Interaction between Radioadaptive Response and Radiation-Induced Bystander Effect in Caenorhabditis elegans: A Unique Role of the DNA Damage Checkpoint

doi:10.1667/RR14548.1

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	Interaction between Radioadaptive Response and Radiation-Induced Bystander Effect in Caenorhabditis elegans: A Unique Role of the DNA Damage Checkpoint
	Tang, Huangqi 1,2,3; Chen, Liangwen 1,2,3; Chen, Lianyun 1,2; Chen, Bin 1,2; Wang, Ting 1,2; Yang, Aifeng 4; Zhan, Furu 1,2; Wu, Lijun 1,2; Bian, Po 1,2
刊名	RADIATION RESEARCH
	2016-12-01
卷号	186 期号:6 页码:662-668
DOI	10.1667/RR14548.1
文献子类	Article
英文摘要	Although radioadaptive responses (RAR) and radiation-induced bystander effects (RIBE) are two important biological effects of low-dose radiation, there are currently only limited data that directly address their interaction, particularly in the context of whole organisms. In previous studies, we separately demonstrated RAR and RIBE using an in vivo system of C. elegans. In the current study, we further investigated their interaction in C. elegans, with the ratio of protruding vulva as the biological end point for RAR. Fourteen-hour-old worms were first locally targeted with a proton microbeam, and were then challenged with a high dose of whole-body gamma radiation. Microbeam irradiation of the posterior pharynx bulbs and rectal valves of C. elegans could significantly suppress the induction of protruding vulva by subsequent gamma irradiation, suggesting a contribution of RIBE to RAR in the context of the whole organism. Moreover, C. elegans has a unique DNA damage response in which the upstream DNA damage checkpoint is not active in most of somatic cells, including vulval cells. However, its impairment in atm-1 and hus-1 mutants blocked the RIBE-initiated RAR of vulva. Similarly, mutations in the atm-1 and hus-1 genes inhibited the RAR of vulva initiated by microbeam irradiation of the vulva itself. These results further confirm that the DNA damage checkpoint participates in the induction of RAR of vulva in C. elegans in a cell nonautonomous manner. (C) 2016 by Radiation Research Society
WOS关键词	REPRODUCTIVE CELL-DEATH ; ADAPTIVE RESPONSE ; GERMLINE CELLS ; TISSUE MODEL ; IRRADIATION
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Biophysics ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
WOS记录号	WOS:000391821400013
资助机构	National Natural Science Foundation of China(U1332127 ; National Natural Science Foundation of China(U1332127 ; National Natural Science Foundation of China(U1332127 ; National Natural Science Foundation of China(U1332127 ; 11275230 ; 11275230 ; 11275230 ; 11275230 ; 11575233) ; 11575233) ; 11575233) ; 11575233) ; National Natural Science Foundation of China(U1332127 ; National Natural Science Foundation of China(U1332127 ; National Natural Science Foundation of China(U1332127 ; National Natural Science Foundation of China(U1332127 ; 11275230 ; 11275230 ; 11275230 ; 11275230 ; 11575233) ; 11575233) ; 11575233) ; 11575233)
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/30594]
专题	合肥物质科学研究院_技术生物与农业工程研究所
作者单位	1.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Ion Beam Bioengn, Hefei 230031, Peoples R China 2.Chinese Acad Sci, Inst Tech Biol & Agr Engn, Key Lab Environm Toxicol & Pollut Control Technol, Hefei 230031, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Peoples R China 4.Hefei Univ Technol, Sch Management, Hefei 23009, Peoples R China
推荐引用方式 GB/T 7714	Tang, Huangqi,Chen, Liangwen,Chen, Lianyun,et al. Interaction between Radioadaptive Response and Radiation-Induced Bystander Effect in Caenorhabditis elegans: A Unique Role of the DNA Damage Checkpoint[J]. RADIATION RESEARCH,2016,186(6):662-668.
APA	Tang, Huangqi.,Chen, Liangwen.,Chen, Lianyun.,Chen, Bin.,Wang, Ting.,...&Bian, Po.(2016).Interaction between Radioadaptive Response and Radiation-Induced Bystander Effect in Caenorhabditis elegans: A Unique Role of the DNA Damage Checkpoint.RADIATION RESEARCH,186(6),662-668.
MLA	Tang, Huangqi,et al."Interaction between Radioadaptive Response and Radiation-Induced Bystander Effect in Caenorhabditis elegans: A Unique Role of the DNA Damage Checkpoint".RADIATION RESEARCH 186.6(2016):662-668.