Enantioselective synthesis of quaternary alpha-aminophosphonates by organocatalytic Friedel-Crafts reactions of indoles with cyclic alpha-ketiminophosphonates

doi:10.1016/S1872-2067(17)62804-3

	Enantioselective synthesis of quaternary alpha-aminophosphonates by organocatalytic Friedel-Crafts reactions of indoles with cyclic alpha-ketiminophosphonates
	Yan, Zhong; Gao, Xiang; Zhou, Yong-Gui
刊名	CHINESE JOURNAL OF CATALYSIS
	2017-05-01
卷号	38 页码:784-792
关键词	Friedel-crafts Reaction Quaternary Alpha-aminophosphonate Indole Chiral Phosphoric Acid
DOI	10.1016/S1872-2067(17)62804-3
英文摘要	An efficient asymmetric Friedel-Crafts reaction has been developed for the synthesis of optically active quaternary alpha-aminophosphonates with up to 98% ee. The synthesis involves the reaction of cyclic alpha-ketiminophosphonates with indoles using an H8-BINOL-derived chiral phosphoric acid (CPA) catalyst that bears electron-withdrawing 3,5-ditrifluoromethylphenyl substituents on its 3- and 3'-positions. This Friedel-Crafts reaction of cyclic alpha-ketiminophosphonates was also successful with pyrrole. (C) 2017, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.
语种	英语
WOS记录号	WOS:000402346400003
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/152281]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Yan, Zhong,Gao, Xiang,Zhou, Yong-Gui. Enantioselective synthesis of quaternary alpha-aminophosphonates by organocatalytic Friedel-Crafts reactions of indoles with cyclic alpha-ketiminophosphonates[J]. CHINESE JOURNAL OF CATALYSIS,2017,38:784-792.
APA	Yan, Zhong,Gao, Xiang,&Zhou, Yong-Gui.(2017).Enantioselective synthesis of quaternary alpha-aminophosphonates by organocatalytic Friedel-Crafts reactions of indoles with cyclic alpha-ketiminophosphonates.CHINESE JOURNAL OF CATALYSIS,38,784-792.
MLA	Yan, Zhong,et al."Enantioselective synthesis of quaternary alpha-aminophosphonates by organocatalytic Friedel-Crafts reactions of indoles with cyclic alpha-ketiminophosphonates".CHINESE JOURNAL OF CATALYSIS 38(2017):784-792.