Chemical genomic analysis of GPR35 signaling

doi:10.1039/c7ib00005g

	Chemical genomic analysis of GPR35 signaling
	Hu, Heidi (Haibei)1,3; Deng, Huayun 3; Ling, Shizhang 3,6; Sun, Haiyan 2,3; Kenakin, Terry 4; Liang, Xinmiao 5; Fang, Ye 3
刊名	INTEGRATIVE BIOLOGY
	2017-05-01
卷号	9 页码:451-463
DOI	10.1039/c7ib00005g
英文摘要	GPR35, a family A orphan G protein-coupled receptor, has been implicated in inflammatory, neurological, and cardiovascular diseases. However, not much is known about the signaling and functions of GPR35. We performed a label-free kinome short hairpin RNA screen and identified a putative signaling network of GPR35 in HT-29 cells, some of which was validated using gene expression, biochemical and cellular assays. The results showed that GPR35 induced hypoxia-inducible factor 1 alpha, and was involved in synaptic transmission, sensory perception, the immune system, and morphogenetic processes. Collectively, our data suggest that GPR35 may play an important role in response to hypoxic stress and be a potential target for the treatment of inflammatory, cardiovascular, and neurological disorders.
语种	英语
WOS记录号	WOS:000401911000007
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/152257]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Carilion Roanoke Mem Hosp, Quest Diagnost Lab, Carilion Clin Hlth Syst, Med Lab Sci,Jefferson Coll Hlth Sci, Roanoke, VA 24013 USA 2.Arizona State Univ, Biodesign Inst, Lab Inflammat & Canc, Tempe, AZ USA 3.Corning Inc, Corning R&D Corp, Biochem Technol, Corning, NY 14831 USA 4.Univ N Carolina, Dept Pharmacol, Sch Med, Chapel Hill, NC 27599 USA 5.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Liaoning, Peoples R China 6.Johns Hopkins Univ, Dept Med, Baltimore, MD USA
推荐引用方式 GB/T 7714	Hu, Heidi ,Deng, Huayun,Ling, Shizhang,et al. Chemical genomic analysis of GPR35 signaling[J]. INTEGRATIVE BIOLOGY,2017,9:451-463.
APA	Hu, Heidi .,Deng, Huayun.,Ling, Shizhang.,Sun, Haiyan.,Kenakin, Terry.,...&Fang, Ye.(2017).Chemical genomic analysis of GPR35 signaling.INTEGRATIVE BIOLOGY,9,451-463.
MLA	Hu, Heidi ,et al."Chemical genomic analysis of GPR35 signaling".INTEGRATIVE BIOLOGY 9(2017):451-463.