Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging

doi:10.1016/j.talanta.2017.04.046

	Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging
	Zhang, Ying 1; Wang, Huihui 1,2; Sun, Dongsheng 1,2; Liao, Han 1,2; Wang, Yanfang 1,2; Zhao, Shan 1,2; Lv, Guojun 1; Ma, Xiaojun 3; Liu, Yang 1; Sun, Guangwei 1
刊名	TALANTA
	2017-08-15
卷号	171 页码:8-15
关键词	Mri Nir Self-assembly Targeted Cellular Imaging Hyaluronic Acid Beta-cyclodextrin
DOI	10.1016/j.talanta.2017.04.046
英文摘要	Multimodal imaging provides distinct advantages over traditional single modal imaging. The combined modalities of magnetic resonance imaging (MRI) and near-infrared imaging (NIR), in particular, provide a powerful tool for tumor diagnosis. In this study, a bimodal MRI and NIR self-assembled supramolecular nanoparticle was developed via the self-assembly of host-guest interactions between hyaluronic acid-beta-cyclodextrin (HA-CD) and amantadine (Ad)-modified imaging agents (Gd-DOTA and NIR cyanine dye Cy7). The supramolecular HA-CD-GC nanoparticles (NPs) were characterized by transmission electron microscopy (TEM), Zeta potential, and dynamic light-scattering (DLS) experiments. The relaxivity and fluorescent properties of the NPs were also determined. HA-CD-GC NPs exhibited an enhanced relaxivity of 11.4 mM(-1)S(-1), which was three-fold higher than that of clinical Gds(3+)-chelated complex, for MRI imaging. Moreover, HA-CD-GC NPs displayed excellent fluorescence. In addition, HA-CD-GC NPs were internalized into tumor cells via HA-receptor CD44-mediated endocytosis. Therefore, the self-assembled HA-CD-GC NPs are effective targeted tumor cell imaging systems and have potential applications in cancer diagnosis and treatment.
语种	英语
WOS记录号	WOS:000403511500002
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/152092]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Stem Cell Grp, Sci Res Ctr Translat Med, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biotechnol, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ying,Wang, Huihui,Sun, Dongsheng,et al. Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging[J]. TALANTA,2017,171:8-15.
APA	Zhang, Ying.,Wang, Huihui.,Sun, Dongsheng.,Liao, Han.,Wang, Yanfang.,...&Sun, Guangwei.(2017).Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging.TALANTA,171,8-15.
MLA	Zhang, Ying,et al."Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular imaging".TALANTA 171(2017):8-15.