Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

doi:10.1038/nm.4358

	Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
	Gu, Yanyun 12; Liu, Ruixin 12; Hong, Jie 12; Xu, Xiaoqiang 13,14; Feng, Qiang 13,15; Zhang, Dongya 13; Shi, Juan 12; Zhao, Shaoqian 12; Liu, Wen 12; Wang, Xiaokai 13,14
刊名	NATURE MEDICINE
	2017-07-01
卷号	23 页码:859-+
DOI	10.1038/nm.4358
英文摘要	Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate concentration. Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota.
语种	英语
WOS记录号	WOS:000405180100015
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/152082]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.BGI Shenzhen, China Natl GeneBank, Shenzhen, Peoples R China 2.Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, Copenhagen, Denmark 3.Natl Inst Nutr & Seafood Res, Bergen, Norway 4.Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA 5.Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA 6.Johns Hopkins Sch Med, Dept Radiol & Radiol Sci, Baltimore, MD USA 7.James D Watson Inst Genome Sci, Hangzhou, Zhejiang, Peoples R China 8.BGI Shenzhen, Shenzhen Key Lab Human Commensal Microorganisms &, Shenzhen, Peoples R China 9.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 10.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Pancreat Dis Ctr,Dept Gen Surg, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Gu, Yanyun,Liu, Ruixin,Hong, Jie,et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention[J]. NATURE MEDICINE,2017,23:859-+.
APA	Gu, Yanyun.,Liu, Ruixin.,Hong, Jie.,Xu, Xiaoqiang.,Feng, Qiang.,...&Wang, Weiqing.(2017).Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention.NATURE MEDICINE,23,859-+.
MLA	Gu, Yanyun,et al."Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention".NATURE MEDICINE 23(2017):859-+.