Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts

	Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts
	Shi, Lei 1,3; Ji, Yue 1,2; Feng, Guang-Shou 1; Chen, Mu-Wang 1; Du, Haifeng 3; Zhou, Yong-Gui 1
刊名	ORGANIC CHEMISTRY FRONTIERS
	2017-06-01
卷号	4 期号:6 页码:1125-1129
英文摘要	An enantioselective hydrogenation of cyclic iminium salts has been successfully realized by employing [Ir(COD)Cl](2) and chiral diphosphine ligands as catalyst, furnishing chiral N-alkyl tetrahydroisoquinolines and N-alkyl tetrahydro-beta-carbolines with up to 96% ee and 88% ee, respectively. The hydrogenation provides a direct, simple and efficient protocol toward chiral tertiary amines. Meanwhile, asymmetric hydrogenation at the gram scale was also conducted smoothly without loss of reactivity and enantioselectivity.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	BETA-CARBOLINE ALKALOIDS ; N-H IMINES ; ENANTIOSELECTIVE SYNTHESIS ; HETEROAROMATIC-COMPOUNDS ; PYRIDINIUM SALTS ; PAENIBACILLUS-LACTIS ; (R)-IMINE REDUCTASE ; AQUEOUS-MEDIA ; ANION-BINDING ; TETRAHYDROISOQUINOLINE
收录类别	SCI
语种	英语
WOS记录号	WOS:000405862600033
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/151911]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Shi, Lei,Ji, Yue,Feng, Guang-Shou,et al. Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts[J]. ORGANIC CHEMISTRY FRONTIERS,2017,4(6):1125-1129.
APA	Shi, Lei,Ji, Yue,Feng, Guang-Shou,Chen, Mu-Wang,Du, Haifeng,&Zhou, Yong-Gui.(2017).Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts.ORGANIC CHEMISTRY FRONTIERS,4(6),1125-1129.
MLA	Shi, Lei,et al."Iridium-catalyzed asymmetric hydrogenation of cyclic iminium salts".ORGANIC CHEMISTRY FRONTIERS 4.6(2017):1125-1129.