Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters

	Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters
	Liu, Yang 1; Lee, Robert J.1,3; Wang, Juan 1; Wang, Di 1; Liu, Chungang 1; Xu, Shiqi 1; An, Shengshu 1; Tang, Siying 1; He, Jian 2
刊名	MOLECULAR MEDICINE REPORTS
	2017-08-01
卷号	16 期号:2 页码:2172-2178
关键词	Paecilomyces tenuipes chronic unpredictable mild stress antidepression neurotransmitters
英文摘要	The medicinal fungus Paecilomyces tenuipes exhibits a variety of pharmacological effects, including antidepressive effects. The chronic unpredictable mild stress (CUMS)-induced rat model has served an important role in studies involving antidepressants screening. The aim of the present study was to evaluate the antidepressant-like activity of P. tenuipes N45 aqueous extract (PTNE) in a CUMS-induced rat model of behavioral despair depression. Following 4 weeks of PTNE treatment, behavioral tests were conducted to investigate the antidepressant-like activities, and the levels of neurotransmitters and hormones in blood and hypothalamus were measured. The results demonstrated that PTNE treatment significantly increased movement in the forced running test, whereas the immobility time was reduced in the hotplate test and the forced swim test in depression-model rats. PTNE treatment was able to normalize the levels of hormones and neurotransmitters in serum and hypothalamus of CUMS rats. The data demonstrated that PTNE treatment may be a potential pharmaceutical agent in treatment-resistant depression, and the effects of PTNE may be partly mediated through normalizing the levels of neurotransmitters.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Oncology ; Medicine, Research & Experimental
研究领域[WOS]	Oncology ; Research & Experimental Medicine
关键词[WOS]	BIOACTIVE COMPOUNDS ; DOPAMINE RELEASE ; MOUSE MODEL ; MICE ; SYSTEM ; ANTIDEPRESSANTS ; DISORDERS ; DISEASE ; AXIS ; EXPRESSION
收录类别	SCI ; SSCI
语种	英语
WOS记录号	WOS:000405079300153
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/151905]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Jilin Univ, Sch Life Sci, 2699 Qianjin St, Changchun 130012, Jilin, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Ctr Translat Med, Dalian 116023, Liaoning, Peoples R China 3.Ohio State Univ, Coll Pharm, Div Pharmaceut, 500 West 12th Ave, Columbus, OH 43201 USA
推荐引用方式 GB/T 7714	Liu, Yang,Lee, Robert J.,Wang, Juan,et al. Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters[J]. MOLECULAR MEDICINE REPORTS,2017,16(2):2172-2178.
APA	Liu, Yang.,Lee, Robert J..,Wang, Juan.,Wang, Di.,Liu, Chungang.,...&He, Jian.(2017).Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters.MOLECULAR MEDICINE REPORTS,16(2),2172-2178.
MLA	Liu, Yang,et al."Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters".MOLECULAR MEDICINE REPORTS 16.2(2017):2172-2178.