Sialic Acid-Responsive Polymeric Interface Material: From Molecular Recognition to Macroscopic Property Switching

	Sialic Acid-Responsive Polymeric Interface Material: From Molecular Recognition to Macroscopic Property Switching
	Li, Xiuling 2,3; Liang, Xinmiao 2; Sun, Taolei 1,4; Xiong, Yuting 1; Jiang, Ge 2; Li, Minmin 1; Qing, Guangyan 1
刊名	SCIENTIFIC REPORTS
	2017-01-13
卷号	7
英文摘要	Biological systems that utilize multiple weak non-covalent interactions and hierarchical assemblies to achieve various bio-functions bring much inspiration for the design of artificial biomaterials. However, it remains a big challenge to correlate underlying biomolecule interactions with macroscopic level of materials, for example, recognizing such weak interaction, further transforming it into regulating material's macroscopic property and contributing to some new bio-applications. Here we designed a novel smart polymer based on polyacrylamide (PAM) grafted with lactose units (PAM-g-lactose(0.11)), and reported carbohydrate-carbohydrate interaction (CCI)-promoted macroscopic properties switching on this smart polymer surface. Detailed investigations indicated that the binding of sialic acid molecules with the grafted lactose units via the CCIs induced conformational transformation of the polymer chains, further resulted in remarkable and reversible switching in surface topography, wettability and stiffness. With these excellent recognition and response capacities towards sialic acid, the PAM-glactose(0.11) further facilitated good selectivity, strong anti-interference and high adsorption capacity in the capture of sialylated glycopeptides (important biomarkers for cancers). This work provides some enlightenment for the development of biointerface materials with tunable property, as well as high-performance glycopeptide enrichment materials.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	CARBOHYDRATE-CARBOHYDRATE INTERACTIONS ; TITANIUM-DIOXIDE CHROMATOGRAPHY ; SELECTIVE ENRICHMENT ; PHENYLBORONIC ACID ; MASS-SPECTROMETRY ; GLYCOPEPTIDE ENRICHMENT ; MAGNETIC NANOPARTICLES ; MESOPOROUS SILICA ; GLYCOPROTEINS ; SYSTEMS
收录类别	SCI
语种	英语
WOS记录号	WOS:000391931500001
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/151877]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, 122 Luoshi Rd, Wuhan 430070, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China 3.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226019, Peoples R China 4.Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, 122 Luoshi Rd, Wuhan 430070, Peoples R China
推荐引用方式 GB/T 7714	Li, Xiuling,Liang, Xinmiao,Sun, Taolei,et al. Sialic Acid-Responsive Polymeric Interface Material: From Molecular Recognition to Macroscopic Property Switching[J]. SCIENTIFIC REPORTS,2017,7.
APA	Li, Xiuling.,Liang, Xinmiao.,Sun, Taolei.,Xiong, Yuting.,Jiang, Ge.,...&Qing, Guangyan.(2017).Sialic Acid-Responsive Polymeric Interface Material: From Molecular Recognition to Macroscopic Property Switching.SCIENTIFIC REPORTS,7.
MLA	Li, Xiuling,et al."Sialic Acid-Responsive Polymeric Interface Material: From Molecular Recognition to Macroscopic Property Switching".SCIENTIFIC REPORTS 7(2017).