Scalable synthesis of secondary and tertiary amines by heterogeneous Pt-Sn/gamma-Al2O3 catalyzed N-alkylation of amines with alcohols

	Scalable synthesis of secondary and tertiary amines by heterogeneous Pt-Sn/gamma-Al2O3 catalyzed N-alkylation of amines with alcohols
	He, Wei; Yu, Zhengkun; Wu, Kaikai; Sun, Chenglin
刊名	TETRAHEDRON
	2016-12-22
卷号	72 期号:51 页码:8516-8521
关键词	Alcohols Alkylation Amines Borrowing hydrogen Pt-Sn/gamma-Al2O3
英文摘要	Synthesis of secondary and tertiary amines has been efficiently realized from the N-alkylation of amines with alcohols by means of heterogeneous bimetallic Pt-Sn/gamma-Al2O3 catalyst (0.5 wt % Pt, molar ratio Pt:Sn = 1:3) through a borrowing hydrogen strategy. The Pt-Sn/gamma-Al2O3 catalyst has exhibited very high catalytic activity towards a wide range of amines andalcohols, and can be conveniently recycled without Pt metal leaching. The present protocol was applied for the synthesis of N-phenylbenzylamine in 96% isolated yield from aniline and benzyl alcohol on a 2.1 kg scale of the substrates, demonstrating its potential applicability for higher-order amine synthesis. (C) 2016 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Organic
关键词[WOS]	BORROWING HYDROGEN METHODOLOGY ; ONE-POT SYNTHESIS ; COUPLING REACTIONS ; PT-SN/AL2O3 CATALYSTS ; SUBSTITUTED AMINES ; ALUMINA SUPPORT ; C-N ; AMINATION ; AMMONIA ; EFFICIENT
收录类别	SCI
语种	英语
WOS记录号	WOS:000389286200021
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/150427]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	He, Wei,Yu, Zhengkun,Wu, Kaikai,et al. Scalable synthesis of secondary and tertiary amines by heterogeneous Pt-Sn/gamma-Al2O3 catalyzed N-alkylation of amines with alcohols[J]. TETRAHEDRON,2016,72(51):8516-8521.
APA	He, Wei,Yu, Zhengkun,Wu, Kaikai,&Sun, Chenglin.(2016).Scalable synthesis of secondary and tertiary amines by heterogeneous Pt-Sn/gamma-Al2O3 catalyzed N-alkylation of amines with alcohols.TETRAHEDRON,72(51),8516-8521.
MLA	He, Wei,et al."Scalable synthesis of secondary and tertiary amines by heterogeneous Pt-Sn/gamma-Al2O3 catalyzed N-alkylation of amines with alcohols".TETRAHEDRON 72.51(2016):8516-8521.