Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS)

	Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS)
	Ni, Chunfang 3; Lian, Ru 1,3; Wu, Zhongping 3; Lv, Xiaobao 3; Rao, Yulan 4; Li, Haiyang 2; Li, Jinghua 2; Wang, Rong 3; Zhang, Yurong 3
刊名	FORENSIC SCIENCE INTERNATIONAL
	2017-10-01
卷号	279 页码:268-280
关键词	Drugs of abuse DAPP-IMS Reduced mobility DART-TOF-MS Rapid screening
英文摘要	Increasing in cases involving drugs of abuse leads to heavy burden for law enforcement agencies, exacerbating demand for rapid screening technique. In this study, atmospheric pressure ionization technologies including direct analysis in real time (DART) ion source coupled to a time-of-flight mass spectrometer (DART-TOF-MS) as well asdopant-assisted positive photoionization ion mobility spectrometry (DAPP-IMS) without radioactivity were utilized together as the powerful analytical tool for the rapid screening and identification of 53 abused drugs. The limits of detection (LOD) were 0.05-2 mu g/mL when using DART-TOF-MS and 0.02-2 mu g when using DAPP-IMS which could satisfy the actual requirement in forensic science laboratory. The advantages of this method included fast response, high-throughput potential, high specificity, and minimal sample preparation. A screening library of reduced mobility (K-0), accurate mass of informative precursor ion ([M+H](+)) and fragment ions was established respectively by employing a bench-top DAPP-IMS and TOF-MS in-source collision induced dissociation (CID) mode. Then the standardized screening procedure was developed with criteria for the confirmation of positive result. A total of 50 seized drug samples provided by local forensic laboratory we reanalyzed to testify the utility of the method. This study suggests that a method combing DART-TOF-MS and DAPP-IMS is promising for the rapid screening and identification of abused drugs with minimal sample preparation and absence of chromatography. (C) 2017 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Medicine, Legal
研究领域[WOS]	Legal Medicine
关键词[WOS]	PSYCHOACTIVE SUBSTANCES ; SYNTHETIC CANNABINOIDS ; ACCUTOF-DART ; IDENTIFICATION ; VALIDATION ; ACCUTOF-DART(TM) ; QUANTIFICATION ; EXPLOSIVES ; DESORPTION ; CATHINONES
收录类别	SCI
语种	英语
WOS记录号	WOS:000411904200038
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/150196]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Shanghai Inst Pharmaceut Ind, China State Inst Pharmaceut Ind, State Key Lab New Drug & Pharmaceut Proc, Shanghai, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China 3.Shanghai Inst Forens Sci, Shanghai Key Lab Crime Scene Evidence, Shanghai, Peoples R China 4.Fudan Univ, Sch Basic Med Sci, Dept Forens Med, Ctr Forens Sci, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Ni, Chunfang,Lian, Ru,Wu, Zhongping,et al. Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS)[J]. FORENSIC SCIENCE INTERNATIONAL,2017,279:268-280.
APA	Ni, Chunfang.,Lian, Ru.,Wu, Zhongping.,Lv, Xiaobao.,Rao, Yulan.,...&Zhang, Yurong.(2017).Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS).FORENSIC SCIENCE INTERNATIONAL,279,268-280.
MLA	Ni, Chunfang,et al."Rapid screening of abused drugs by direct analysis in real time (DART) coupled to time-of-flight mass spectrometry (TOF-MS) combined with ion mobility spectrometry (IMS)".FORENSIC SCIENCE INTERNATIONAL 279(2017):268-280.