A Short-Wavelength Raman Optical Activity Spectrometer with Laser Source at 457nm for the Characterization of Chiral Molecules

	A Short-Wavelength Raman Optical Activity Spectrometer with Laser Source at 457nm for the Characterization of Chiral Molecules
	Li, Can 2; Zhang, Ying 2; Wang, Peng 1,2; Jia, Guoqing 2; Cheng, Feng 2; Feng, Zhaochi 2
刊名	APPLIED SPECTROSCOPY
	2017-09-01
卷号	71 期号:9 页码:2211-2217
关键词	Raman optical activity ROA short-wavelength laser 457nm ROA enhanced ROA signal-to-noise ratio
英文摘要	Developing a high-sensitivity Raman optical activity (ROA) spectrometer has been regarded as one of the great challenges in chiral science and technology. Herein, we report our recent progress on the development of a short-wavelength ROA (sw-ROA) spectrometer with the excitation line at 457nm, which shows obviously improved signal-to-noise (S/N) ratio compared with the currently available 532nm ROA spectrometer. This could be ascribed to the fifth-power of frequency dependence for ROA intensity together with the potential advantage of avoiding fluorescence for most molecules. The required laser power at the sample for being able to obtain a reliable ROA spectrum is less than 150 milliwatts (mW) for most samples. In the case of neat S--pinene sample, the ROA signal can be acquired with the laser power at sample as low as 5 mW with the total exposure time of 5min. The concentration of S--pinene sample can be reduced to 10% (v/v) by diluting with ethanol. These results demonstrate the great potential of sw-ROA (457nm) working with decreased laser power, shortened acquisition time, and lower sample concentration. The applicability of sw-ROA (457nm) has also been demonstrated by measuring representative chiral samples, including carbohydrates, amino acids, protein in aqueous solution, and chiral organic molecule in organic solvents.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Instruments & Instrumentation ; Spectroscopy
研究领域[WOS]	Instruments & Instrumentation ; Spectroscopy
关键词[WOS]	ACTIVITY SPECTROSCOPY ; SCATTERING
收录类别	SCI
语种	英语
WOS记录号	WOS:000408851300016
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/149961]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Li, Can,Zhang, Ying,Wang, Peng,et al. A Short-Wavelength Raman Optical Activity Spectrometer with Laser Source at 457nm for the Characterization of Chiral Molecules[J]. APPLIED SPECTROSCOPY,2017,71(9):2211-2217.
APA	Li, Can,Zhang, Ying,Wang, Peng,Jia, Guoqing,Cheng, Feng,&Feng, Zhaochi.(2017).A Short-Wavelength Raman Optical Activity Spectrometer with Laser Source at 457nm for the Characterization of Chiral Molecules.APPLIED SPECTROSCOPY,71(9),2211-2217.
MLA	Li, Can,et al."A Short-Wavelength Raman Optical Activity Spectrometer with Laser Source at 457nm for the Characterization of Chiral Molecules".APPLIED SPECTROSCOPY 71.9(2017):2211-2217.