Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways

	Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways
	Tang, Miao 1,3,4; Zhang, Xiao Chuan 1,3,4; Shi, Yun Wei 1,3,4; Wang, Cai Ping 1,3,4; Ding, Fei 1,3,4; Liang, Xin Miao 1,3,4,5; Wang, Zhi Wei 1,2,3,4; Chen, Chen 1,3,4
刊名	BRAIN BEHAVIOR AND IMMUNITY
	2017-11-01
卷号	66 页码:244-256
关键词	C5aR1 TLR4 Schisantherin A Inflammation Apoptosis Neuroprotection
英文摘要	Toll-like receptor 4 (TLR4) and C5aR1 (CD88) have been recognized as potential therapeutic targets for the reduction of inflammation and secondary damage and improvement of outcome after ischemia and reperfusion (I/R). The inflammatory responses which induce cell apoptosis and necrosis after I/R brain injury lead to a limited process of neural repair. To further comprehend how these targets function in I/R state, we investigated the pathological changes and TLR4 and C5aR1 signaling pathways in vitro and in vivo models of I/12 brain injury in this study. Meanwhile, we explored the roles of schisantherin A on I/R brain injury, and whether it exerted neuroprotective effects by regulating the TLR4 and C5aR1 signaling pathways or not. The results showed that schisantherin A significantly reduced the neuronal apoptosis induced by oxygen and glucose deprivation and reperfusion (OGD/R) injury in primary culture of rat cortical neurons. Also, schisantherin A alleviated neurological deficits, reduced infarct volume, attenuated oxidation stress, inflammation and apoptosis in ischemic parietal cortex of rats after middle cerebral artery occlusion and reperfusion (MCAO/R) injury. Moreover, the activated TLR4 and C5aR1 signaling pathways were inhibited by schisantherin A treatment. In conclusion, TLR4 and C5aR1 played a vital role during I/R. brain injury in rats, and schisantherin A exhibited neuroprotective effects by TLR4 and C5aR1 signaling pathways. These findings also provided new insights that would aid in elucidating the effect of schisantherin A against cerebral I/12 and support the development of schisantherin A as a potential treatment for ischemic stroke. (C) 2017 Elsevier Inc. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Immunology ; Neurosciences
研究领域[WOS]	Immunology ; Neurosciences & Neurology
关键词[WOS]	FOCAL CEREBRAL-ISCHEMIA ; NF-KAPPA-B ; IN-VIVO ; DIBENZOCYCLOOCTADIENE LIGNANS ; FUNCTIONAL RECOVERY ; BRAIN-INJURY ; ACUTE STROKE ; PROTECTS ; COMPLEMENT ; RECEPTOR
收录类别	SCI
语种	英语
WOS记录号	WOS:000414236600025
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/149713]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Jiangsu, Peoples R China 2.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA 3.Nantong Univ, Key Lab Neuroregenerat Jiangsu, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China 4.Nantong Univ, Minist Educ, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China 5.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Tang, Miao,Zhang, Xiao Chuan,Shi, Yun Wei,et al. Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways[J]. BRAIN BEHAVIOR AND IMMUNITY,2017,66:244-256.
APA	Tang, Miao.,Zhang, Xiao Chuan.,Shi, Yun Wei.,Wang, Cai Ping.,Ding, Fei.,...&Chen, Chen.(2017).Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways.BRAIN BEHAVIOR AND IMMUNITY,66,244-256.
MLA	Tang, Miao,et al."Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways".BRAIN BEHAVIOR AND IMMUNITY 66(2017):244-256.