Fibroblast growth factor 2 protects against renal ischaemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling | |
Tan, Xiao-Hua6; Zheng, Xiao-Meng6; Yu, Li-Xia6; He, Jian1; Zhu, Hong-Mei6; Ge, Xiu-Ping2; Ren, Xiao-Li4; Ye, Fa-Qing6; Bellusci, Saverio3,5; Xiao, Jian6 | |
刊名 | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE |
2017-11-01 | |
卷号 | 21期号:11页码:2909-2925 |
关键词 | fibroblast growth factor 2 High-mobility group box 1 ischaemia-reperfusion acute kidney injury mitochondrial dysfunction inflammatory cytokine |
英文摘要 | Ischaemia-reperfusion injury (I/RI) is a common cause of acute kidney injury (AKI). The molecular basis underlying I/RI-induced renal pathogenesis and measures to prevent or reverse this pathologic process remains to be resolved. Basic fibroblast growth factor (FGF2) is reported to have protective roles of myocardial infarction as well as in several other I/R related disorders. Herein we present evidence that FGF2 exhibits robust protective effect against renal histological and functional damages in a rat I/RI model. FGF2 treatment greatly alleviated I/R-induced acute renal dysfunction and largely blunted I/R-induced elevation in serum creatinine and blood urea nitrogen, and also the number of TUNEL-positive tubular cells in the kidney. Mechanistically, FGF2 substantially ameliorated renal I/RI by mitigating several mitochondria damaging parameters including pro-apoptotic alteration of Bcl2/Bax expression, caspase-3 activation, loss of mitochondrial membrane potential and K-ATP channel integrity. Of note, the protective effect of FGF2 was significantly compromised by the K-ATP channel blocker 5-HD. Interestingly, I/RI alone resulted in mild activation of FGFR, whereas FGF2 treatment led to more robust receptor activation. More significantly, post-I/RI administration of FGF2 also exhibited robust protection against I/RI by reducing cell apoptosis, inhibiting the release of damage-associated molecular pattern molecule HMBG1 and activation of its downstream inflammatory cytokines such as IL-1 alpha, IL-6 and TNF alpha. Taken together, our data suggest that FGF2 offers effective protection against I/RI and improves animal survival by attenuating mitochondrial damage and HMGB1-mediated inflammatory response. Therefore, FGF2 has the potential to be used for the prevention and treatment of I/RI-induced AKI. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Cell Biology ; Medicine, Research & Experimental |
研究领域[WOS] | Cell Biology ; Research & Experimental Medicine |
关键词[WOS] | ISCHEMIA-REPERFUSION INJURY ; ACUTE KIDNEY INJURY ; CARDIAC-SPECIFIC OVEREXPRESSION ; SENSITIVE K+-CHANNEL ; DEPENDENT POTASSIUM CHANNEL ; OXIDATIVE STRESS ; REACTIVE OXYGEN ; NEPHROGENIC PROTEINS ; CEREBRAL-ISCHEMIA ; CELL APOPTOSIS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000413962100024 |
内容类型 | 期刊论文 |
源URL | [http://cas-ir.dicp.ac.cn/handle/321008/149701] |
专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Ctr Translat Med, Dalian, Liaoning, Peoples R China 2.Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Pediat Surg, Xian, Shaanxi, Peoples R China 3.Wenzhou Univ, Inst Life Sci, Wenzhou, Peoples R China 4.Wenzhou Med Univ, Lab Anim Ctr, Wenzhou, Zhejiang, Peoples R China 5.Justus Liebig Univ, Excellence Cluster Cardiopulm Syst, Giessen, Germany 6.Wenzhou Med Univ, Sch Pharmaceut Sci, Key Lab Biotechnol & Pharmaceut Engn, Wenzhou, Zhejiang, Peoples R China |
推荐引用方式 GB/T 7714 | Tan, Xiao-Hua,Zheng, Xiao-Meng,Yu, Li-Xia,et al. Fibroblast growth factor 2 protects against renal ischaemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2017,21(11):2909-2925. |
APA | Tan, Xiao-Hua.,Zheng, Xiao-Meng.,Yu, Li-Xia.,He, Jian.,Zhu, Hong-Mei.,...&Zhang, Jin-San.(2017).Fibroblast growth factor 2 protects against renal ischaemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,21(11),2909-2925. |
MLA | Tan, Xiao-Hua,et al."Fibroblast growth factor 2 protects against renal ischaemia/reperfusion injury by attenuating mitochondrial damage and proinflammatory signalling".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 21.11(2017):2909-2925. |
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