NB-3 signaling mediates the cross-talk between post-traumatic spinal axons and scar-forming cells

doi:10.15252/embj.201593460

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	NB-3 signaling mediates the cross-talk between post-traumatic spinal axons and scar-forming cells
	Huang, ZH; Gao, YR; Sun, YH; Zhang, C; Yin, Y; Shimoda, Y; Watanabe, K; Liu, YB; Liu, YB (reprint author), Soochow Univ, Jiangsu Key Lab Translat Res & Therapy Neuropsych, Inst Neurosci, Suzhou, Peoples R China.
刊名	EMBO JOURNAL
	2016-08-15
卷号	35 期号:16 页码:1745-1765
关键词	NB-3 axonal regeneration spinal cord injury
ISSN号	0261-4189
DOI	10.15252/embj.201593460
文献子类	Article
英文摘要	Little is known about the molecules mediating the cross-talk between post-traumatic axons and scar-forming cells after spinal cord injury. We found that a sustained NB-3 induction was simultaneously present in the terminations of post-traumatic corticospinal axons and scar-forming cells at the spinal lesion site, where they were in direct contact when axons tried to penetrate the glial scar. The regrowth of corticospinal axons was enhanced in vivo with NB-3 deficiency or interruption of NB-3 trans-homophilic interactions. Biochemical, in vitro and in vivo evidence demonstrated that NB-3 homophilically interacted in trans to initiate a growth inhibitory signal transduction from scar-forming cells to neurons by modulating mTOR activity via CHL1 and PTP sigma. NB-3 deficiency promoted BMS scores, electrophysiological transmission, and synapse reformation between regenerative axons and neurons. Our findings demonstrate that NB-3 trans-homophilic interactions mediate the cross-talk between post-traumatic axons and scarforming cells and impair the intrinsic growth ability of injured axons.
学科主题	Biochemistry & Molecular Biology ; Cell Biology
出版地	HOBOKEN
资助项目	国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划（973计划）
项目编号	National Natural Sciences Foundation of China [81330026, 31271259, 30990261, 30871425] ; National Key Basic Research Development Program of the Ministry of Science and Technology of China (973 Program) [2013CB945600] ; Chinese Academy of Sciences [KSCX2-EW-Q-11] ; Priority Academic Program Development of Jiangsu Higher Education Institutions
语种	英语
WOS记录号	WOS:000382317500005
资助机构	NSFC ; MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/178494]
专题	学院待认领_期刊论文
通讯作者	Liu, YB (reprint author), Soochow Univ, Jiangsu Key Lab Translat Res & Therapy Neuropsych, Inst Neurosci, Suzhou, Peoples R China.
推荐引用方式 GB/T 7714	Huang, ZH,Gao, YR,Sun, YH,et al. NB-3 signaling mediates the cross-talk between post-traumatic spinal axons and scar-forming cells[J]. EMBO JOURNAL,2016,35(16):1745-1765.
APA	Huang, ZH.,Gao, YR.,Sun, YH.,Zhang, C.,Yin, Y.,...&Liu, YB .(2016).NB-3 signaling mediates the cross-talk between post-traumatic spinal axons and scar-forming cells.EMBO JOURNAL,35(16),1745-1765.
MLA	Huang, ZH,et al."NB-3 signaling mediates the cross-talk between post-traumatic spinal axons and scar-forming cells".EMBO JOURNAL 35.16(2016):1745-1765.