Three Preservation Solutions for Cold Storage of Heart Allografts: A Systematic Review and Meta-Analysis

doi:10.1111/aor.12585

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	Three Preservation Solutions for Cold Storage of Heart Allografts: A Systematic Review and Meta-Analysis
	Li, YN; Guo, SS; Liu, G; Yuan, Y; Wang, W; Zheng, Z; Hu, SS; Ji, BY; Ji, BY (reprint author), Chinese Acad Med Sci, Dept Cardiopulm Bypass, State Key Lab Cardiovasc Med, Fuwai Hosp,Natl Ctr Cardiovasc Dis, 167 Beilishi Rd, Beijing 100037, Peoples R China.; Ji, BY (reprint author), Peking Union Med Coll, 167 Beilishi Rd, Beijing 100037, Peoples R China.
	2016-05
会议日期	MAY 18-21, 2016
会议地点	Columbia Univ Med Ctr, New York Presbyterian, Vivian & Seymour Milstein Fa, New York, NY
关键词	Heart Transplantation Organ Preservation Organ Preservation Solution Systematic Review
卷号	40
期号	5
DOI	10.1111/aor.12585
页码	489-496
英文摘要	Organ preservation solution has been designed to attenuate the detrimental effects during the ischemic period. The aim of this study was to systematically evaluate the evidence comparing preservation solutions for heart preservation. Studies were searched in PubMed, Embase, the Cochrane Library, the Transplant Library, and the International Clinical Trials Registry Platform. The primary outcomes were patient survival and donor heart dysfunction. The secondary outcomes were in-hospital mortality and enzyme gene expression. The University of Wisconsin solution (UW) was associated with a significantly improved survival at 30 days and 90 days (hazard ratio = 1.16, 95% confidence interval [CI] = 1.11-1.22, P < 0.00001; risk difference [RD] = 0.03, 95% CI = 0.01-0.05, P = 0.002), compared with Celsior. Hearts preserved with UW exhibited less ischemic necrosis than those preserved with Celsior (RD = -0.07, 95% CI = -0.08 to 0.05, P < 0.00001). UW was associated with better survival compared with histidine-tryptophan-ketoglutarate solution (HTK). There was no statistical difference in donor heart dysfunction and in-hospital mortality outcomes when comparing HTK with Celsior solution. During static cold storage preservation, this study suggests that UW solution has better clinical outcomes for heart transplantation compared with the other two organ preservation solutions. Besides, the protective effect of Celsior solution is similar to HTK solution in donor heart preservation.
会议录	ARTIFICIAL ORGANS
资助机构	Columbia Univ Med Ctr, New York Presbyterian, Vivian & Seymour Milstein Fa ; Columbia Univ Med Ctr, New York Presbyterian, Vivian & Seymour Milstein Fa ; Columbia Univ Med Ctr, New York Presbyterian, Vivian & Seymour Milstein Fa ; Columbia Univ Med Ctr, New York Presbyterian, Vivian & Seymour Milstein Fa
会议录出版地	HOBOKEN
学科主题	Engineering ; Transplantation
语种	英语
ISSN号	0160-564X
WOS记录号	WOS:000378542800015
内容类型	会议论文
源URL	[http://ir.lzu.edu.cn/handle/262010/183002]
专题	第二临床医学院_会议论文
通讯作者	Ji, BY (reprint author), Chinese Acad Med Sci, Dept Cardiopulm Bypass, State Key Lab Cardiovasc Med, Fuwai Hosp,Natl Ctr Cardiovasc Dis, 167 Beilishi Rd, Beijing 100037, Peoples R China.; Ji, BY (reprint author), Peking Union Med Coll, 167 Beilishi Rd, Beijing 100037, Peoples R China.
推荐引用方式 GB/T 7714	Li, YN,Guo, SS,Liu, G,et al. Three Preservation Solutions for Cold Storage of Heart Allografts: A Systematic Review and Meta-Analysis[C]. 见:. Columbia Univ Med Ctr, New York Presbyterian, Vivian & Seymour Milstein Fa, New York, NY. MAY 18-21, 2016.