Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc

doi:10.3892/ijo.2016.3674

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	Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc
	Wei, YC; Zhao, L; He, WT; Yang, JW; Geng, CY; Chen, YS; Liu, T; Chen, H; Li, YM; Li, YM (reprint author), Lanzhou Univ, Hosp 2, Key Lab Digest Syst Tumors Gansu Prov, 82 Cuiyingmen, Lanzhou 730030, Gansu, Peoples R China.
刊名	INTERNATIONAL JOURNAL OF ONCOLOGY
	2016-11
卷号	49 期号:5 页码:2055-2063
关键词	benzo[a]pyrene gastric cancer proliferation metastasis Aryl hydrocarbon receptor ERK MMP9 c-myc
ISSN号	1019-6439
DOI	10.3892/ijo.2016.3674
文献子类	Article
英文摘要	Gastric cancer (GC) is the fifth most common cancer worldwide and the third leading cause of global cancer-related death. Benzo[a]pyrene (BaP), a Group I carcinogen categorized by the IARC, is a cumulative foodborne carcinogen and ubiquitous environmental pollutant with potent carcinogenic properties. However, the function and mechanism of BaP exposure on GC progression remains unclear. We investigated the role of BaP in human GC progression to identify potential mechanism underlining its carcinogenic activity. After exposure to various concentrations of BaP, human GC cells SGC-7901 and MNK-45 showed an increased capability of proliferation, migration and invasion. Further study indicated that BaP promotes the expression of matrix metalloproteinase-9 (MMP9) and c-myc at mRNA and protein level, and activates Aryl hydrocarbon receptor (AhR) and ERK pathway. Moreover, BaP-induced overexpression of MMP9 and c-myc were attenuated by the ERK inhibitor U0126 and AhR inhibitor resveratrol, respectively. These data suggest that BaP promotes proliferation and metastasis of GC cells through upregulation of MMP9 and c-myc expression, and this was likely mediated via the AhR and ERK signaling pathway.
学科主题	Oncology
出版地	ATHENS
资助项目	国家自然科学基金项目 ; 中央高校基本科研业务费专项资金
项目编号	National Natural Science Foundation of China [31270532] ; Central college basic scientific research foundation of Lanzhou university [lzujbky-2013-m04]
语种	英语
WOS记录号	WOS:000386539400029
资助机构	NSFC ; LZU
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188700]
专题	第二临床医学院_期刊论文
通讯作者	Li, YM (reprint author), Lanzhou Univ, Hosp 2, Key Lab Digest Syst Tumors Gansu Prov, 82 Cuiyingmen, Lanzhou 730030, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Wei, YC,Zhao, L,He, WT,et al. Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2016,49(5):2055-2063.
APA	Wei, YC.,Zhao, L.,He, WT.,Yang, JW.,Geng, CY.,...&Li, YM .(2016).Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc.INTERNATIONAL JOURNAL OF ONCOLOGY,49(5),2055-2063.
MLA	Wei, YC,et al."Benzo[a]pyrene promotes gastric cancer cell proliferation and metastasis likely through the Aryl hydrocarbon receptor and ERK-dependent induction of MMP9 and c-myc".INTERNATIONAL JOURNAL OF ONCOLOGY 49.5(2016):2055-2063.