Clinical and Prognostic Effect of Plasma Fibrinogen in Renal Cell Carcinoma: A Meta-Analysis

doi:10.1155/2017/9591506

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	Clinical and Prognostic Effect of Plasma Fibrinogen in Renal Cell Carcinoma: A Meta-Analysis
	Tian, YJ; Hong, M; Jing, SS; Liu, XC; Wang, HZ; Wang, XP; Kaushik, D; Rodriguez, R; Wang, ZP; Wang, ZP (reprint author), Lanzhou Univ, Inst Urol, Hosp 2, Key Lab Gansu Prov Urol Dis,Gansu Nephrourol Clin, Lanzhou 730030, Peoples R China.
刊名	BIOMED RESEARCH INTERNATIONAL
	2017
ISSN号	2314-6133
DOI	10.1155/2017/9591506
文献子类	Review
英文摘要	Background. Although numerous studies have shown that plasma fibrinogen is linked to renal cell carcinoma (RCC) risk, the consistency and magnitude of the effect of plasma fibrinogen are unclear. The aim of the study was to explore the association between plasma fibrinogen and RCC prognosis. Methods. An electronic search of Embase, PubMed/MEDLINE, and the Cochrane databases was performed to identify relevant studies published prior to June 1, 2016. Results. A total of 3744 patients with RCC from 7 published studies were included in the meta-analysis. The prognostic and clinical relevance of plasma fibrinogen are evaluated in RCC patients. Statistical significance of the combined hazard ratio (HR) was detected for overall survival, cancer-specific survival, and disease-free survival. Our pooled results showed that elevated plasma fibrinogen was significantly associated with clinical stage and Fuhrman grading. The level of plasma fibrinogen was not found to be associated with tumor type and gender. Conclusions. Elevated plasma fibrinogen is a strong indicator of poorer prognosis of patients with RCC, whereas the plasma fibrinogen is not significantly associated with tumor type. Therefore, plasma fibrinogen could be used in patients with RCC for risk stratification and decision providing a proper therapeutic strategy.
学科主题	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
出版地	NEW YORK
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of China [81372733/H1619] ; National Science Foundation of China [81302240]
语种	英语
WOS记录号	WOS:000392581100001
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188687]
专题	第二临床医学院_期刊论文
通讯作者	Wang, ZP (reprint author), Lanzhou Univ, Inst Urol, Hosp 2, Key Lab Gansu Prov Urol Dis,Gansu Nephrourol Clin, Lanzhou 730030, Peoples R China.
推荐引用方式 GB/T 7714	Tian, YJ,Hong, M,Jing, SS,et al. Clinical and Prognostic Effect of Plasma Fibrinogen in Renal Cell Carcinoma: A Meta-Analysis[J]. BIOMED RESEARCH INTERNATIONAL,2017.
APA	Tian, YJ.,Hong, M.,Jing, SS.,Liu, XC.,Wang, HZ.,...&Wang, ZP .(2017).Clinical and Prognostic Effect of Plasma Fibrinogen in Renal Cell Carcinoma: A Meta-Analysis.BIOMED RESEARCH INTERNATIONAL.
MLA	Tian, YJ,et al."Clinical and Prognostic Effect of Plasma Fibrinogen in Renal Cell Carcinoma: A Meta-Analysis".BIOMED RESEARCH INTERNATIONAL (2017).