Intermittent hormone therapy versus continuous hormone therapy for locally advanced prostate cancer: a meta-analysis

doi:10.3109/13685538.2015.1065245

CORC > 兰州大学 > 兰州大学 > 第二临床医学院 > 期刊论文

	Intermittent hormone therapy versus continuous hormone therapy for locally advanced prostate cancer: a meta-analysis
	Dong, ZL; Wang, HZ; Xu, MM; Li, Y; Hou, ML; Wei, YL; Liu, XC; Wang, ZP; Xie, XD; Xie, XD (reprint author), Lanzhou Univ, Sch Basic Med Sci, Lanzhou 730000, Gansu, Peoples R China.
刊名	AGING MALE
	2015-10-02
卷号	18 期号:4 页码:233-237
关键词	Hormone therapy meta-analysis prostate cancer
ISSN号	1368-5538
DOI	10.3109/13685538.2015.1065245
文献子类	Article
英文摘要	Few randomized studies have compared intermittent hormone therapy (IHT) with continuous hormone therapy (CHT) for the treatment of locally advanced prostate cancer (PCa). Here, we report the results of a meta-analysis of a randomized controlled trial, evaluating the effectiveness of IHT versus CHT for patients with locally advanced PCa. Types of intervention were IHT versus CHT. The primary endpoint of this study is overall mortality and the secondary endpoints are any progression of disease, quality of life (QOL) and adverse effects between two groups. Six randomized controlled trials totaling 2996 patients were included. Results are as follows: after hormone therapy, patients undergoing IHT demonstrated no significant difference from those undergoing CHT in terms of the overall mortality (OR=1.0, 95% CI [0.86, 1.17]) and disease progression (OR=1.16, 95% CI [0.86, 1.57]). Men treated with IHT also reported better QOL, fewer adverse effects and considerable economic benefit for the individual and the community. With no difference in overall mortality and incidence of progression, current clinical studies confirm that both therapeutic methods were safe and effective. However, our study also takes into account QOL. When these secondary measures are considered, IHT may be a better option over CHT as patients report a more affordable treatment with improved QOL and fewer adverse effects.
学科主题	Endocrinology & Metabolism ; Urology & Nephrology
出版地	ABINGDON
资助项目	中国博士后科学基金
项目编号	China Postdoctoral Science Foundation
语种	英语
WOS记录号	WOS:000365642000005
资助机构	CPSF
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179401]
专题	第二临床医学院_期刊论文
通讯作者	Xie, XD (reprint author), Lanzhou Univ, Sch Basic Med Sci, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Dong, ZL,Wang, HZ,Xu, MM,et al. Intermittent hormone therapy versus continuous hormone therapy for locally advanced prostate cancer: a meta-analysis[J]. AGING MALE,2015,18(4):233-237.
APA	Dong, ZL.,Wang, HZ.,Xu, MM.,Li, Y.,Hou, ML.,...&Xie, XD .(2015).Intermittent hormone therapy versus continuous hormone therapy for locally advanced prostate cancer: a meta-analysis.AGING MALE,18(4),233-237.
MLA	Dong, ZL,et al."Intermittent hormone therapy versus continuous hormone therapy for locally advanced prostate cancer: a meta-analysis".AGING MALE 18.4(2015):233-237.