FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis

doi:10.1007/s12032-015-0656-1

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	FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis
	Fu, Y; Lin, YC; Yang, Z; Yang, GS; Li, GY; Liu, YJ; Tan, X; Huang, Y; Wu, X; Wang, YQ
刊名	MEDICAL ONCOLOGY
	2015-08
卷号	32 期号:8
关键词	FBXW7 RCC Cell cycle Apoptosis Proliferation
ISSN号	1357-0560
DOI	10.1007/s12032-015-0656-1
文献子类	Article
英文摘要	FBXW7 gene (F-box and WD-40 domain protein 7) is also named HCDC4 and is a significant tumor suppressor gene, which can regulate human cell cycle, proliferation and differentiation. In this study, we tend to investigate protein expression and related biological functions of FBXW7 gene. FBXW7 expression level in renal cell carcinoma (RCC) tissues is highly related to its clinical pathologic grade (P = 0.0094) and TNM phase (P = 0.0080) and is highly lower than in paracancerous normal tissues through immunohistochemistry study. FBXW7 high-expression patients have overall better prognosis than low-expression patients (P < 0.001). After transfected with FBXW7 plasmid, the RCC cell lines ACHN and A704 showed a depressed proliferation activity and high proportion of apoptosis through CCK8, colony formation and flow cytometry assay studies. By Western blot analysis, expression of cell proliferation-activating protein c-Myc and c-Jun is downregulated in FBXW7 high-expression RCC compared with negative control. These data suggested that FBXW7 is a significant tumor suppressor gene in RCC.
学科主题	Oncology
出版地	TOTOWA
语种	英语
WOS记录号	WOS:000358667700006
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179382]
专题	第二临床医学院_期刊论文
通讯作者	Yang, GS (reprint author), Univ South China, Collaborat Hosp, Guangdong Prov Peoples Hosp 2, Dept Urol, Guangzhou 510317, Guangdong, Peoples R China.
推荐引用方式 GB/T 7714	Fu, Y,Lin, YC,Yang, Z,et al. FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis[J]. MEDICAL ONCOLOGY,2015,32(8).
APA	Fu, Y.,Lin, YC.,Yang, Z.,Yang, GS.,Li, GY.,...&Yang, GS .(2015).FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis.MEDICAL ONCOLOGY,32(8).
MLA	Fu, Y,et al."FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis".MEDICAL ONCOLOGY 32.8(2015).