Prokinetic Activity of Prunus persica (L.) Batsch Flowers Extract and Its Possible Mechanism of Action in Rats

doi:10.1155/2015/569853

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	Prokinetic Activity of Prunus persica (L.) Batsch Flowers Extract and Its Possible Mechanism of Action in Rats
	Han, W; Xu, JD; Wei, FX; Zheng, YD; ZhongMa, J; Xu, XD; Wei, ZG; Wang, W; Zhang, YC; Zhang, YC (reprint author), Lanzhou Univ, Hosp 2, Hepato Biliary Pancreat Inst, Dept Gen Surg, Lanzhou 730030, Peoples R China.
刊名	BIOMED RESEARCH INTERNATIONAL
	2015
ISSN号	2314-6133
DOI	10.1155/2015/569853
文献子类	Article
英文摘要	The peach tree, Prunus persica (L.) Batsch, is widely cultivated in China, and its flowers have been used for centuries in traditional Chinese medicine to treat gut motility disorders. But few studies have explored the pharmacological effect of Prunus persica (L.) Batsch flowers on gastrointestinal motility. In this study, the activities of different extracts from Prunus persica (L.) Batsch flowers on the smooth muscle contractions were evaluated using isolated colon model, and the ethyl acetate extract (EAE) showed the strongest effects in vitro. EAE (10(-8)-10(-5) g/mL) caused a concentration-dependent stimulatory effect in rat colonic tissue. Additionally, ketotifen (100 mu M), cimetidine (10 mu M), and pyrilamine (1 mu M) produced a significant inhibition of contractions caused by EAE. Furthermore, immunofluorescence and toluidine blue staining revealed increased numbers of mast cells in the EAE group, and EAE increased histamine release from the colonic tissues. These data indicate that EAE has significant prokinetic activity and acts by a mechanism that mainly involves mast cell degranulation. Our study provides a pharmacological basis for the use of an extract of Prunus persica (L.) Batsch flowers in the treatment of gut motility disorders.
学科主题	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
出版地	NEW YORK
资助项目	甘肃省科技支撑计划
项目编号	Science and Technology Pillar Program of Gansu Province, China [1204FKCA138]
语种	英语
WOS记录号	WOS:000351375900001
资助机构	GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179317]
专题	第二临床医学院_期刊论文
通讯作者	Zhang, YC (reprint author), Lanzhou Univ, Hosp 2, Hepato Biliary Pancreat Inst, Dept Gen Surg, Lanzhou 730030, Peoples R China.
推荐引用方式 GB/T 7714	Han, W,Xu, JD,Wei, FX,et al. Prokinetic Activity of Prunus persica (L.) Batsch Flowers Extract and Its Possible Mechanism of Action in Rats[J]. BIOMED RESEARCH INTERNATIONAL,2015.
APA	Han, W.,Xu, JD.,Wei, FX.,Zheng, YD.,ZhongMa, J.,...&Zhang, YC .(2015).Prokinetic Activity of Prunus persica (L.) Batsch Flowers Extract and Its Possible Mechanism of Action in Rats.BIOMED RESEARCH INTERNATIONAL.
MLA	Han, W,et al."Prokinetic Activity of Prunus persica (L.) Batsch Flowers Extract and Its Possible Mechanism of Action in Rats".BIOMED RESEARCH INTERNATIONAL (2015).