Childhood Sexual Abuse and the Development of Recurrent Major Depression in Chinese Women

doi:10.1371/journal.pone.0087569

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	Childhood Sexual Abuse and the Development of Recurrent Major Depression in Chinese Women
	Chen, J; Cai, YY; Cong, EZ; Liu, Y; Gao, JF; Li, YH; Tao, M; Zhang, KR; Wang, XM; Gao, CG
刊名	PLOS ONE
	2014-01-29
卷号	9 期号:1 页码:-
ISSN号	1932-6203
DOI	10.1371/journal.pone.0087569
文献子类	Article
英文摘要	Background: Our prior study in Han Chinese women has shown that women with a history of childhood sexual abuse (CSA) are at increased risk for developing major depression (MD). Would this relationship be found in our whole data set? Method: Three levels of CSA (non-genital, genital, and intercourse) were assessed by self-report in two groups of Han Chinese women: 6017 clinically ascertained with recurrent MD and 5983 matched controls. Diagnostic and other risk factor information was assessed at personal interview. Odds ratios (ORs) were calculated by logistic regression. Results: We confirmed earlier results by replicating prior analyses in 3,950 new recurrent MD cases. There were no significant differences between the two data sets. Any form of CSA was significantly associated with recurrent MD (OR 4.06, 95% confidence interval (CI) [3.19-5.24]). This association strengthened with increasing CSA severity: non-genital (OR 2.21, 95% CI 1.58-3.15), genital (OR 5.24, 95% CI 3.52-8.15) and intercourse (OR 10.65, 95% CI 5.56-23.71). Among the depressed women, those with CSA had an earlier age of onset, longer depressive episodes. Recurrent MD patients those with CSA had an increased risk for dysthymia (OR 1.60, 95% CI 1.11-2.27) and phobia (OR 1.41, 95% CI 1.09-1.80). Any form of CSA was significantly associated with suicidal ideation or attempt (OR 1.50, 95% CI 1.20-1.89) and feelings of worthlessness or guilt (OR 1.41, 95% CI 1.02-2.02). Intercourse (OR 3.47, 95% CI 1.66-8.22), use of force and threats (OR 1.95, 95% CI 1.05-3.82) and how strongly the victims were affected at the time (OR 1.39, 95% CI 1.20-1.64) were significantly associated with recurrent MD. Conclusions: In Chinese women CSA is strongly associated with recurrent MD and this association increases with greater severity of CSA. Depressed women with CSA have some specific clinical traits. Some features of CSA were associated with greater likelihood of developing recurrent MD.
学科主题	Science & Technology - Other Topics
出版地	SAN FRANCISCO
资助项目	英国惠康基金会项目
项目编号	Wellcome Trust [083240/Z/07/2]
语种	英语
WOS记录号	WOS:000330570000161
资助机构	Wellcome Trust
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/126186]
专题	第二临床医学院_期刊论文
通讯作者	Shi, SX (reprint author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China.
推荐引用方式 GB/T 7714	Chen, J,Cai, YY,Cong, EZ,et al. Childhood Sexual Abuse and the Development of Recurrent Major Depression in Chinese Women[J]. PLOS ONE,2014,9(1):-.
APA	Chen, J.,Cai, YY.,Cong, EZ.,Liu, Y.,Gao, JF.,...&Shi, SX .(2014).Childhood Sexual Abuse and the Development of Recurrent Major Depression in Chinese Women.PLOS ONE,9(1),-.
MLA	Chen, J,et al."Childhood Sexual Abuse and the Development of Recurrent Major Depression in Chinese Women".PLOS ONE 9.1(2014):-.