Comparison of pharmacological and electrical cardioversion in permanent atrial fibrillation after prosthetic cardiac valve replacement: A prospective randomized trial

doi:10.1177/0300060513489800

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	Comparison of pharmacological and electrical cardioversion in permanent atrial fibrillation after prosthetic cardiac valve replacement: A prospective randomized trial
	Chen, WS; Gao, BR; Chen, WQ; Li, ZZ; Xu, ZY; Zhang, YH; Yang, K; Guan, XQ; Gao, BR (reprint author), Lanzhou Univ, Hosp 2, Dept Cardiac Surg, 82 Cui Ying Men St, Lanzhou 730030, Gansu, Peoples R China.
刊名	JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
	2013-08
卷号	41 期号:4 页码:1067-1073
关键词	Electrical cardioversion permanent atrial fibrillation pharmacological cardioversion prosthetic cardiac valve replacement
ISSN号	0300-0605
DOI	10.1177/0300060513489800
文献子类	Article
英文摘要	Objective: To compare the efficacy of electrical versus pharmacological cardioversion following prosthetic cardiac valve replacement in patients with permanent atrial fibrillation (AF). Methods: Patients with permanent AF who had undergone prosthetic cardiac valve replacement, who had a cardiothoracic ratio 0.5 and a left atrial diameter 50mm for 6months after surgery were randomly divided to receive either electrical or pharmacological cardioversion. Patients in the electrical cardioversion group were given direct-current synchronized electrical defibrillation under general anaesthesia. Patients in the pharmacological cardioversion group were given oral combination therapy with amiodarone, captopril and simvastatin for 3 months. Results: A total of 115 patients received either electrical cardioversion (n=59) or pharmacological cardioversion (n=56); reversion to sinus rhythm occurred in 98.3% and 26.8%, respectively. Recurrence rates were similar in the two groups (3.4% and 6.7% for electrical and pharmacological cardioversion, respectively). No deaths or severe complications were reported. Conclusion: Electrical cardioversion has a favourable safety profile and appears to be a more effective method than pharmacological cardioversion for the treatment of permanent AF after cardiac valve replacement, once the heart has returned close to its normal size.
学科主题	Research & Experimental Medicine ; Pharmacology & Pharmacy
出版地	LONDON
语种	英语
WOS记录号	WOS:000322507100016
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/126161]
专题	第二临床医学院_期刊论文
通讯作者	Gao, BR (reprint author), Lanzhou Univ, Hosp 2, Dept Cardiac Surg, 82 Cui Ying Men St, Lanzhou 730030, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Chen, WS,Gao, BR,Chen, WQ,et al. Comparison of pharmacological and electrical cardioversion in permanent atrial fibrillation after prosthetic cardiac valve replacement: A prospective randomized trial[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2013,41(4):1067-1073.
APA	Chen, WS.,Gao, BR.,Chen, WQ.,Li, ZZ.,Xu, ZY.,...&Gao, BR .(2013).Comparison of pharmacological and electrical cardioversion in permanent atrial fibrillation after prosthetic cardiac valve replacement: A prospective randomized trial.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,41(4),1067-1073.
MLA	Chen, WS,et al."Comparison of pharmacological and electrical cardioversion in permanent atrial fibrillation after prosthetic cardiac valve replacement: A prospective randomized trial".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 41.4(2013):1067-1073.