Antibiotic prophylaxis in transarterial therapy of hepatocellular carcinoma: A meta-analysis

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	Antibiotic prophylaxis in transarterial therapy of hepatocellular carcinoma: A meta-analysis
	Wang, J; He, XD; Zhang, YC; Zhang, YC (reprint author), Lanzhou Univ, Dept Gen Surg, Hosp 2, Lanzhou 730030, Gansu, Peoples R China.
刊名	CANADIAN JOURNAL OF GASTROENTEROLOGY
	2012-02
卷号	26 期号:2 页码:85-91
关键词	Antibiotic prophylaxis Hepatocellular carcinoma Infection Meta-analysis Transarterial therapy
ISSN号	0835-7900
文献子类	Article
英文摘要	J Wang, XD He, YC Zhang. Antibiotic prophylaxis in transarterial therapy of hepatocellular carcinoma: A meta-analysis. Can J Gastroenterol 2012;26(2):85-91. BACKGROUND: The use of prophylactic antibiotics against post-procedure infection in patients undergoing transarterial therapy for hepatocellular carcinoma is controversial. AIM: To compare the effects of prophylactic antibiotic treatment and no prophylactic antibiotic treatment on infectious complications following transarterial procedures. METHODS: Clinical trials fulfilling predefined selection criteria were identified by searching several bibliographic databases; a meta-analysis was performed where appropriate. RESULTS: Four trials of inadequate quality consisting of 210 patients were included in the analysis. Only one case of possible post-procedure infection in each group was reported. The rate of patients developing fever (RR 0.91 [95% CI 0.61 to 1.35]), changes in peripheral white blood cell count or serum C-reactive protein levels, and the mean length of hospital stay (mean difference 0.20 [95% CI 0.75 to 1.14]) showed no significant intergroup differences between antibiotic and no antibiotic treatment. Furthermore, the results of the present study indicated that the incidence of bacteremia, septicemia, sepsis or hepatic abscess after transarterial therapy was rare. CONCLUSION: Antibiotic prophylaxis in patients undergoing transarterial therapy for hepatocellular carcinoma may not be routinely necessary. However, a more judicious use of antibiotics is recommended for patients who are at an increased risk of infection. Nevertheless, prospective trials on a larger scale are clearly needed.
学科主题	Gastroenterology & Hepatology
出版地	OAKVILLE
资助项目	甘肃省自然科学基金计划
项目编号	Natural Science Foundation of Gansu Province, China [096RJZA070]
语种	英语
WOS记录号	WOS:000299994200005
资助机构	GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/126096]
专题	第二临床医学院_期刊论文
通讯作者	Zhang, YC (reprint author), Lanzhou Univ, Dept Gen Surg, Hosp 2, Lanzhou 730030, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Wang, J,He, XD,Zhang, YC,et al. Antibiotic prophylaxis in transarterial therapy of hepatocellular carcinoma: A meta-analysis[J]. CANADIAN JOURNAL OF GASTROENTEROLOGY,2012,26(2):85-91.
APA	Wang, J,He, XD,Zhang, YC,&Zhang, YC .(2012).Antibiotic prophylaxis in transarterial therapy of hepatocellular carcinoma: A meta-analysis.CANADIAN JOURNAL OF GASTROENTEROLOGY,26(2),85-91.
MLA	Wang, J,et al."Antibiotic prophylaxis in transarterial therapy of hepatocellular carcinoma: A meta-analysis".CANADIAN JOURNAL OF GASTROENTEROLOGY 26.2(2012):85-91.