Genomic Analyses of Recombinant Adenovirus Type 11a in China

doi:10.1128/JCM.00282-09

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	Genomic Analyses of Recombinant Adenovirus Type 11a in China
	Yang, ZH; Zhu, Z; Tang, LY; Wang, L; Tan, XJ; Yu, PB; Zhang, Y; Tian, XP; Wang, JJ; Zhang, Y
刊名	JOURNAL OF CLINICAL MICROBIOLOGY
	2009-10
卷号	47 期号:10 页码:3082-3090
ISSN号	0095-1137
DOI	10.1128/JCM.00282-09
文献子类	Article
英文摘要	Whole-genome sequencing of human adenovirus type 11 (HAdV-11) strain QS, isolated in China, was conducted, and its sequence was compared with the sequences of strains within the species of HAdVs. The HAdV-11 QS genome contains 34,755 nucleotides. Similar to the other HAdV subgenus B sequences, the HAdV-11 QS genome coded 37 functional proteins and could be divided into four early, two intermediate, and five late transcription regions. The amino acid sequences of the fiber and the hypervariable regions (HVRs) within the hexon gene of HAdV-11 QS were identical to the corresponding sequences of the HAdV-11a strain; further analyses that compared those amino acid sequences with the amino acid sequences of the HAdV species subgenus B: 2 strains revealed that the highest degree of homology (>99.2%) existed between HAdV-11 QS and the prototypical HAdV-14 strain, except for a few coding sequences of HVRs within the hexon gene, DNA polymerase, pVI, and pre-terminal protein. This indicate that HAdV-11 strain QS, isolated in China, is a recombinant adenovirus of HAdV-14, and the recombination analyses also confirmed this finding. It is difficult to clarify the time and manner of the recombination, and further investigations are required to determine whether the emergence of recombination between HAdV-11a and HAdV-14 might increase virulence, thereby posing a new global challenge with regard to acute respiratory diseases in the near future.
学科主题	Microbiology
出版地	WASHINGTON
资助项目	国家高技术研究发展计划（863计划） ; 国家科技重大专项
项目编号	Ministry of Science and Technology of the People's Republic of China [2007AA02Z463, 2009ZX1004-201, 2009ZX1004-202]
语种	英语
WOS记录号	WOS:000270351700002
资助机构	MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/126004]
专题	第二临床医学院_期刊论文
通讯作者	Xu, WB (reprint author), Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, State Key Lab Mol Virol & Genet Engn, 27 Nanwei Rd, Beijing 100050, Peoples R China.
推荐引用方式 GB/T 7714	Yang, ZH,Zhu, Z,Tang, LY,et al. Genomic Analyses of Recombinant Adenovirus Type 11a in China[J]. JOURNAL OF CLINICAL MICROBIOLOGY,2009,47(10):3082-3090.
APA	Yang, ZH.,Zhu, Z.,Tang, LY.,Wang, L.,Tan, XJ.,...&Xu, WB .(2009).Genomic Analyses of Recombinant Adenovirus Type 11a in China.JOURNAL OF CLINICAL MICROBIOLOGY,47(10),3082-3090.
MLA	Yang, ZH,et al."Genomic Analyses of Recombinant Adenovirus Type 11a in China".JOURNAL OF CLINICAL MICROBIOLOGY 47.10(2009):3082-3090.