Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model

doi:10.1016/j.canlet.2008.01.041

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	Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model
	Tian, BQ; Wang, ZP; Zhao, YM; Wang, DG; Li, YG; Ma, L; Li, XM; Li, J; Xiao, N; Tian, JQ
刊名	CANCER LETTERS
	2008-06-18
卷号	264 期号:2 页码:299-308
关键词	bladder carcinoma transitional cell curcumin inhibition apoptosis
ISSN号	0304-3835
DOI	10.1016/j.canlet.2008.01.041
文献子类	Article
英文摘要	Curcumin, a well-known dietary pigment derived from Curcuma longa, inhibited growth of several types of malignant cells both in vivo and in vitro. Its effects on cell proliferation and the induction of apoptosis in human bladder cancer cell lines and intravesical activity in a rat bladder tumor model were studied. Exposure of human bladder cancer cells to curcumin resulted in the induction of apoptotic cell death and caused cells to arrest in the G2/M phase. The anti-apoptotic Bcl-2 and Survivin protein was downregulated by the curcumin treatment together with enhancement of the Bax and p53 expression. The inhibitory activities of curcumin were stronger than those of cisplatin and could not be prevented by catalase pretreatment in T24 cells. Clonal assay indicated large-dose and short-term curcumin was lethal to bladder cancer cells. Moreover, the in vivo study revealed curcumin did induce apoptosis in situ, inhibit and slow the development of bladder cancer. These observations suggest that curcumin could prove an effective chemopreventive and chemotherapy agent for bladder cancer. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
学科主题	Oncology
出版地	CLARE
语种	英语
WOS记录号	WOS:000256776900016
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125985]
专题	第二临床医学院_期刊论文
通讯作者	Wang, ZP (reprint author), Lanzhou Univ, Hosp 2, Inst Urol, 80 Cuiyingmen St, Lanzhou 730030, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Tian, BQ,Wang, ZP,Zhao, YM,et al. Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model[J]. CANCER LETTERS,2008,264(2):299-308.
APA	Tian, BQ.,Wang, ZP.,Zhao, YM.,Wang, DG.,Li, YG.,...&Wang, ZP .(2008).Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model.CANCER LETTERS,264(2),299-308.
MLA	Tian, BQ,et al."Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model".CANCER LETTERS 264.2(2008):299-308.