The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI-ET cycles in a Chinese population

doi:10.1007/s10815-016-0793-2

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	The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI-ET cycles in a Chinese population
	Xu, XJ; Zhang, R; Wang, W; Liu, HF; Liu, L; Mao, B; Zeng, XW; Zhang, XH; Zhang, XH (reprint author), Lanzhou Univ, Reprod Med Hosp, Hosp 1, Lanzhou, Gansu, Peoples R China.
刊名	JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
	2016-11
卷号	33 期号:11 页码:1481-1486
关键词	Chromosomal polymorphisms Clinical outcomes IVF/ICSI cycles Fertilization rate Cleavage rate
ISSN号	1058-0468
DOI	10.1007/s10815-016-0793-2
文献子类	Article
英文摘要	Chromosomal polymorphisms (CPs) have been reported to be associated with infertility; however, their effects on the outcomes of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) are still controversial. In this retrospective study, we aimed to evaluate the effect of CPs on IVF/ICSI-ET outcomes. To investigate whether CPs affected the outcomes of fresh IVF/ICSI-ET cycles in a Chinese population, we evaluated infertile couples with male carriers of CPs (n = 348), infertile couples with female carriers (n = 99), and unaffected couples (n = 400) who had received their first treatment cycles in our hospital between January 2013 and March 2015. CPs in either male or female carriers seemed to have adverse effects on IVF/ICSI-ET outcomes. CPs in male carriers affected outcomes mainly by decreasing the rates of fertilization, embryo cleavage, good quality embryos, clinical pregnancies, ongoing pregnancies, and deliveries as well as increasing the biochemical pregnancy rate (P < 0.05); CPs in female carriers affected outcomes only by lowering the embryo cleavage rate (P < 0.05). The mean fertilization rate of couples with male CP carriers undergoing IVF was significantly lower than that in those undergoing ICSI (61.1 versus 66.5 %, respectively; P = 0.0004). Our data provide evidence for the involvement of CPs in the poor outcomes of fresh IVF/ICSI-ET cycles in a Chinese population. The use of ICSI might improve outcomes by increasing the fertilization rate for men with CPs.
学科主题	Genetics & Heredity ; Obstetrics & Gynecology ; Reproductive Biology
出版地	NEW YORK
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of People's Republic of China [313010232, 81401261]
语种	英语
WOS记录号	WOS:000389192200010
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188658]
专题	第一临床医学院_期刊论文
通讯作者	Xu, XJ; Zhang, XH (reprint author), Lanzhou Univ, Reprod Med Hosp, Hosp 1, Lanzhou, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Xu, XJ,Zhang, R,Wang, W,et al. The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI-ET cycles in a Chinese population[J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,2016,33(11):1481-1486.
APA	Xu, XJ.,Zhang, R.,Wang, W.,Liu, HF.,Liu, L.,...&Zhang, XH .(2016).The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI-ET cycles in a Chinese population.JOURNAL OF ASSISTED REPRODUCTION AND GENETICS,33(11),1481-1486.
MLA	Xu, XJ,et al."The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI-ET cycles in a Chinese population".JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 33.11(2016):1481-1486.