MCRT, a chimeric peptide based on morphiceptin and PFRTic-NH2, regulates the depressor effects induced by endokinin A/B

doi:10.1016/j.ejphar.2016.10.028

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	MCRT, a chimeric peptide based on morphiceptin and PFRTic-NH2, regulates the depressor effects induced by endokinin A/B
	Zhang, J; He, CB; Pi, X; Wang, Y; Zhou, LX; Dong, SL; Dong, SL (reprint author), Sch Life Sci, Inst Biochem & Mol Biol, 222 Tianshui South Rd, Lanzhou 730000, Peoples R China.; Zhou, LX (reprint author), Lanzhou Univ, Affiliated Hosp 1, Core Lab, 1 Donggang West Rd, Lanzhou 730000, Peoples R China.
刊名	EUROPEAN JOURNAL OF PHARMACOLOGY
	2016-12-05
卷号	792 页码:33-37
关键词	Endokinin A/B MCRT Co-injection Depressor effect
ISSN号	0014-2999
DOI	10.1016/j.ejphar.2016.10.028
文献子类	Article
英文摘要	The interactions of the chimeric peptide MCRT (YPFPFRTic-NH2), based on morphiceptin and neuropeptide FF derivative PFRTic-NH2, on the effects of endokinin A/B (EKA/B) on mean arterial blood pressure of the urethane-anaesthetized rat have been investigated in the absence and presence of tachykinin receptor antagonists, naloxone and NO synthase inhibitors. While MCRT produced dose dependent decreases in mean arterial pressure, in its presence only a small but statistically insignificant decreases in the magnitude and the time course of the depressor effect of EKA/B (10 nmol/kg) were observed. MCRT had little influence on the depressor effect of EKA/B (1 nmol/kg), but strongly potentiated that of EKA/B (100 nmol/kg). The tachykinin NK1 receptor antagonist SR140333B (1 mg/kg) and the NK3 antagonist SR142891 (2.79 mg/kg) both reduced the hypotensive effects of EKA/B and MCRT alone and blocked those of the two peptides in combination. The NK2 antagonist GR159897 (4 mg/kg) partially blocked the depressor effects of EKA/B and MCRT alone. Naloxone (2 mg/kg) completely blocked the depressor effect of MCTR, but partially blocked that of EKA/B. The NO synthase inhibitor L-NAME (50 mg/kg) partially blocked the depressor effects of EKA/B, MCRT, and EKA/B + MCRT. These results could help to better understand the role of tachykinin receptors, opioid receptors and neuropeptide FF receptors in cardiovascular system.
学科主题	Pharmacology & Pharmacy
出版地	AMSTERDAM
资助项目	中央高校基本科研业务费专项资金 ; 甘肃省重点实验室资助项目
项目编号	Fundamental Research Funds for the Central Universities [lzujbky-2013-154] ; foundation of Key Laboratory for Gastrointestinal Diseases of Gansu Province [gswcky-2012-006]
语种	英语
WOS记录号	WOS:000390645900005
资助机构	LZU ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188633]
专题	第一临床医学院_期刊论文
通讯作者	Dong, SL (reprint author), Sch Life Sci, Inst Biochem & Mol Biol, 222 Tianshui South Rd, Lanzhou 730000, Peoples R China.; Zhou, LX (reprint author), Lanzhou Univ, Affiliated Hosp 1, Core Lab, 1 Donggang West Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, J,He, CB,Pi, X,et al. MCRT, a chimeric peptide based on morphiceptin and PFRTic-NH2, regulates the depressor effects induced by endokinin A/B[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2016,792:33-37.
APA	Zhang, J.,He, CB.,Pi, X.,Wang, Y.,Zhou, LX.,...&Zhou, LX .(2016).MCRT, a chimeric peptide based on morphiceptin and PFRTic-NH2, regulates the depressor effects induced by endokinin A/B.EUROPEAN JOURNAL OF PHARMACOLOGY,792,33-37.
MLA	Zhang, J,et al."MCRT, a chimeric peptide based on morphiceptin and PFRTic-NH2, regulates the depressor effects induced by endokinin A/B".EUROPEAN JOURNAL OF PHARMACOLOGY 792(2016):33-37.