Pain regulation of endokinin A/B or endokinin C/D on chimeric peptide MCRT in mice

doi:10.1139/cjpp-2015-0554

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	Pain regulation of endokinin A/B or endokinin C/D on chimeric peptide MCRT in mice
	He, CB; Gong, JB; Yang, LX; Zhang, HW; Dong, SL; Zhou, LX; Dong, SL (reprint author), Sch Life Sci, Inst Biochem & Mol Biol, 222 Tianshui South Rd, Lanzhou 730000, Peoples R China.; Dong, SL (reprint author), Key Lab Preclin Study New Drugs Gansu Prov, 222 Tianshui South Rd, Lanzhou 730000, Peoples R China.; Zhou, LX (reprint author), Lanzhou Univ, Affiliated Hosp 1, Core Lab, 1 Donggang West Rd, Lanzhou 730000, Peoples R China.; Zhou, LX (reprint author), Key Lab Gastrointestinal Dis Gansu Prov, Lanzhou 730000, Peoples R China.
刊名	CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
	2016-09
卷号	94 期号:9 页码:955-960
关键词	endokinin A/B endokinin C/D MCRT NK1 receptor opioid receptors pain regulation co-injection
ISSN号	0008-4212
DOI	10.1139/cjpp-2015-0554
文献子类	Article
英文摘要	The present study focused on the interactive pain regulation of endokinin A/B (EKA/B, the common C-terminal decapeptide in EKA and EKB) or endokinin C/D (EKC/D, the common C-terminal duodecapeptide in EKC and EKD) on chimeric peptide MCRT (YPFPFRTic-NH2, based on YPFP-NH2 and PFRTic-NH2) at the supraspinal level in mice. Results demonstrated that the co-injection of nanomolar EKA/B and MCRT showed moderate regulation, whereas 30 pmol EKA/B had no effect on MCRT. The combination of EKC/D and MCRT produced enhanced antinociception, which was nearly equal to the sum of the mathematical values of single EKC/D and MCRT. Mechanism studies revealed that pre-injected naloxone attenuated the combination significantly compared with the equivalent analgesic effects of EKC/D alone, suggesting that EKC/D and MCRT might act on two totally independent pathways. Moreover, based on the above results and previous reports, we made two reasonable hypotheses to explain the cocktail-induced analgesia, which may potentially pave the way to explore the respective regulatory mechanisms of EKA/B, EKC/D, and MCRT and to better understand the complicated pain regulation of NK1 and mu opioid receptors, as follows: (1) MCRT and endomorphin-1 possibly activated different mu subtypes; and (2) picomolar EKA/B might motivate the endogenous NPFF system after NK1 activation.
学科主题	Pharmacology & Pharmacy ; Physiology
出版地	OTTAWA
资助项目	中央高校基本科研业务费专项资金 ; 甘肃省卫生厅资助项目
项目编号	Fundamental Research Funds for the Central Universities [lzujbky-2013-154] ; Foundation of Key Laboratory for Gastrointestinal Diseases of Gansu Province [gswcky-2012-006] ; Health Industry Research Project of Gansu Province [GWGL2014-54]
语种	英语
WOS记录号	WOS:000382755800005
资助机构	LZU ; GSPHD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/178669]
专题	第一临床医学院_期刊论文
通讯作者	Dong, SL (reprint author), Sch Life Sci, Inst Biochem & Mol Biol, 222 Tianshui South Rd, Lanzhou 730000, Peoples R China.; Dong, SL (reprint author), Key Lab Preclin Study New Drugs Gansu Prov, 222 Tianshui South Rd, Lanzhou 730000, Peoples R China.; Zhou, LX (reprint author), Lanzhou Univ, Affiliated Hosp 1, Core Lab, 1 Donggang West Rd, Lanzhou 730000, Peoples R China.; Zhou, LX (reprint author), Key Lab Gastrointestinal Dis Gansu Prov, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	He, CB,Gong, JB,Yang, LX,et al. Pain regulation of endokinin A/B or endokinin C/D on chimeric peptide MCRT in mice[J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY,2016,94(9):955-960.
APA	He, CB.,Gong, JB.,Yang, LX.,Zhang, HW.,Dong, SL.,...&Zhou, LX .(2016).Pain regulation of endokinin A/B or endokinin C/D on chimeric peptide MCRT in mice.CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY,94(9),955-960.
MLA	He, CB,et al."Pain regulation of endokinin A/B or endokinin C/D on chimeric peptide MCRT in mice".CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 94.9(2016):955-960.