Up-regulation of Plasma Hexosylceramide (d18:1/18:1) Contributes to Genotype 2 Virus Replication in Chronic Hepatitis C A 20-Year Cohort Study

doi:10.1097/MD.0000000000003773

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	Up-regulation of Plasma Hexosylceramide (d18:1/18:1) Contributes to Genotype 2 Virus Replication in Chronic Hepatitis C A 20-Year Cohort Study
	Zhang, JY; Qu, F; Li, JF; Liu, M; Ren, F; Zhang, JY; Bian, DD; Chen, Y; Duan, ZP; Zhang, JL
刊名	MEDICINE
	2016-06
卷号	95 期号:23
ISSN号	0025-7974
DOI	10.1097/MD.0000000000003773
文献子类	Article
英文摘要	The aim of the present study was to explore the relationship between plasma sphingolipids and hepatitis C virus (HCV) replication in chronic hepatitis C (CHC) patients. A cohort of 120 treatment-naive CHC patients was included. Liver biopsies and the Scheuer scoring system were used to assess hepatic inflammatory activity. Blood biochemical indicators, HCV-RNA load, and immunological markers were also measured. Forty-four plasma sphingolipids were identified and quantified using high-performance liquid chromatography-tandem mass spectrometry. The hexosylceramide (HexCer) (d18:1/18:1) level was significantly different between patients with a low HCV load (<10(6) IU/mL) and a high HCV load (>= 10(6) IU/mL), and it was positively correlated with the HCV-RNA load (r = 0.337, P = 0.001) in CHC patients. Additionally, the plasma HexCer (d18:1/18:1) level (odds ratio 1.302, 95% confidence interval 1.129-1.502) was an independent factor for a high HCV-RNA load. For patients with hepatic inflammation grade <= 2 or HCV genotype 2, HexCer (d18:1/18:1) was independently related to a high HCV-RNA load. Plasma HexCer (d18:1/18:1) might be involved in the high viral replication level in chronic HCV infection, especially for CHC patients with genotype 2.
学科主题	General & Internal Medicine
出版地	PHILADELPHIA
资助项目	国家科技重大专项
项目编号	Ministry of Science and Technology of People's Republic of China [2012ZX09301002-006] ; Beijing Municipal Science & Technology Commission [Z131107002213019, Z151100004015066] ; National Key Subject Construction Project [WJWYA-2014-002] ; Beijing Municipal Administration of Hospital [XM201308] ; Scientific Research Base Construction-Collaborative Innovation Center for the Major Infectious Diseases Prevention and Control [115215] ; Base to Clinical Scientific Research Cooperation Fund of Capital Medical University [15JL67]
语种	英语
WOS记录号	WOS:000378051500014
资助机构	MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/178655]
专题	第一临床医学院_期刊论文
通讯作者	Duan, ZP; Zheng, SJ (reprint author), Capital Med Univ, Beijing YouAn Hosp, Artificial Liver Ctr, 8 Xitoutiao,Youwai St, Beijing 100069, Peoples R China.; Zhang, JL (reprint author), Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, 2 Nanwei Rd, Beijing 100050, Peoples R China.; Zhang, JL (reprint author), Peking Union Med Coll, 2 Nanwei Rd, Beijing 100050, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, JY,Qu, F,Li, JF,et al. Up-regulation of Plasma Hexosylceramide (d18:1/18:1) Contributes to Genotype 2 Virus Replication in Chronic Hepatitis C A 20-Year Cohort Study[J]. MEDICINE,2016,95(23).
APA	Zhang, JY.,Qu, F.,Li, JF.,Liu, M.,Ren, F.,...&Zhang, JL .(2016).Up-regulation of Plasma Hexosylceramide (d18:1/18:1) Contributes to Genotype 2 Virus Replication in Chronic Hepatitis C A 20-Year Cohort Study.MEDICINE,95(23).
MLA	Zhang, JY,et al."Up-regulation of Plasma Hexosylceramide (d18:1/18:1) Contributes to Genotype 2 Virus Replication in Chronic Hepatitis C A 20-Year Cohort Study".MEDICINE 95.23(2016).