Association Between the Change in Body Mass Index from Early Adulthood to Midlife and Subsequent Type 2 Diabetes Mellitus

doi:10.1002/oby.21336

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	Association Between the Change in Body Mass Index from Early Adulthood to Midlife and Subsequent Type 2 Diabetes Mellitus
	Sun, WW; Shi, LX; Ye, Z; Mu, YM; Liu, C; Zhao, JJ; Chen, LL; Li, Q; Yang, T; Yan, L
刊名	OBESITY
	2016-03
卷号	24 期号:3 页码:703-709
ISSN号	1930-7381
DOI	10.1002/oby.21336
文献子类	Article
英文摘要	Objective: To clarify the quantitative relationship of body mass index (BMI) change from early adulthood to midlife with presence of type 2 diabetes mellitus (T2DM) after midlife. Methods: This study included 120,666 middle-aged and elderly, whose retrospectively self-reported body weight at 20 and 40 years and measured height were available. BMI at 20 and 40 years and BMI change in between were defined as early-adulthood BMI, midlife BMI, and early-adulthood BMI change. Results: The odds ratio (OR) for T2DM associated with an 1-unit increment of early-adulthood or midlife BMI was 1.08 (95% confidence interval (CI), 1.07-1.08) and 1.09 (95% CI, 1.09-1.10) respectively. In the cross-tabulation of both early-adulthood BMI and BMI change, the prevalence of T2DM increased across both variables. Compared with participants with normal early-adulthood weight and BMI increase/decrease <= 1, the OR (95% CI) for T2DM of participants with early-adulthood overweight/obesity and BMI increase >= 4 kg/m(2) was 3.49 (3.05-4.00). For participants with early-adulthood underweight and BMI increase/decrease <= 1, the OR (95% CI) was 0.85 (0.75-0.97). Subgroup analysis according to sex and age showed similar trends. Conclusions: Early-adulthood BMI may influence T2DM prevalence after midlife independent of current BMI. T2DM prevalence after midlife was positively associated with early-adulthood weight gain and inversely related to early-adulthood weight loss, while early-adulthood weight loss could not completely negate the adverse effect of early-adulthood overweight/obesity on diabetes.
学科主题	Endocrinology & Metabolism ; Nutrition & Dietetics
出版地	HOBOKEN
资助项目	国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划（973计划） ; 国家科技支撑计划 ; 国家科技重大专项
项目编号	China National Clinical Research Center for Metabolic Diseases [2013BAI09B13] ; 973 Program [2015CB553600] ; National Key New Drug Creation and Manufacturing Program of Ministry of Science and Technology [2012ZX09303006-001] ; National Natural Science Foundation of China [81321001, 81390350, 81222008, 81170719, 81130016]
语种	英语
WOS记录号	WOS:000372003800026
资助机构	NSFC ; MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/178631]
专题	第一临床医学院_期刊论文
通讯作者	Wang, WQ (reprint author), Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Natl Clin Res Ctr Metab Dis, Shanghai 200030, Peoples R China.
推荐引用方式 GB/T 7714	Sun, WW,Shi, LX,Ye, Z,et al. Association Between the Change in Body Mass Index from Early Adulthood to Midlife and Subsequent Type 2 Diabetes Mellitus[J]. OBESITY,2016,24(3):703-709.
APA	Sun, WW.,Shi, LX.,Ye, Z.,Mu, YM.,Liu, C.,...&Wang, WQ .(2016).Association Between the Change in Body Mass Index from Early Adulthood to Midlife and Subsequent Type 2 Diabetes Mellitus.OBESITY,24(3),703-709.
MLA	Sun, WW,et al."Association Between the Change in Body Mass Index from Early Adulthood to Midlife and Subsequent Type 2 Diabetes Mellitus".OBESITY 24.3(2016):703-709.