Genetic polymorphisms of the multidrug resistance 1 gene MDR1 and the risk of hepatocellular carcinoma

doi:10.1007/s13277-015-3407-1

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	Genetic polymorphisms of the multidrug resistance 1 gene MDR1 and the risk of hepatocellular carcinoma
	Wang, ZC; Liu, LZ; Liu, XY; Hu, JJ; Wu, YN; Shi, JY; Yang, LX; Duan, M; Wang, XY; Zhou, J
刊名	TUMOR BIOLOGY
	2015-09
卷号	36 期号:9 页码:7007-7015
关键词	Gene polymorphism Hepatocellular carcinoma Meta-analysis Multiple drug resistance 1 gene
ISSN号	1010-4283
DOI	10.1007/s13277-015-3407-1
文献子类	Article
英文摘要	A possible association between multiple drug resistance 1 gene (MDR1) polymorphisms and the risk of developing hepatocellular carcinoma (HCC) is currently under debate, and evidence from various epidemiological studies has yielded controversial results. To derive a more precise estimation of the association between MDR1 polymorphisms and HCC risk, the present meta-analysis was performed. A total of 8 studies containing 11 cohorts with 4407 cases and 4436 controls were included by systematic literature search of EMBASE, PubMed, Web of Science, and CNKI. All polymorphisms were classified as mutant/wild-type alleles. In particular, the variation type, functional impact, and protein domain location of the polymorphisms were assessed and used as stratified indicators. The pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated to evaluate the association. Overall, our results suggested that the mutant alleles of the MDR1 gene were associated with a significantly increased risk for HCC under all genetic models (allelic model: OR = 1.28, 95 % CI = 1.20-1.36, P < 0.001; dominant model: OR = 1.27, 95 % CI = 1.16-1.38, P < 0.001; recessive model: OR = 1.59, 95 % CI = 1.36-1.85, P < 0.001). Furthermore, increased risks for HCC were also revealed in stratified analyses by ethnicity, sample size, and quality scores of cohorts as well as variation type, functional impact, and protein domain location of polymorphisms. In conclusion, the present meta-analysis suggested that the presence of MDR1 mutant alleles might be a risk factor for HCC.
学科主题	Oncology
出版地	DORDRECHT
资助项目	国家自然科学基金项目 ; 国家科技重大专项 ; 高等学校全国优秀博士学位论文作者专项资金
项目编号	Major Program of NSFC [81030038] ; National Key Sci-Tech Project [2012ZX10002011-002] ; National Natural Science Foundation of China [81372648, 81272730, 81272725] ; FANEDD [201183] ; Shanghai "Promising Youth Medical Worker" Project [13Y055]
语种	英语
WOS记录号	WOS:000365033100049
资助机构	NSFC ; MOST ; MOE
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/178594]
专题	第一临床医学院_期刊论文
通讯作者	Gao, Q (reprint author), Fudan Univ, Zhongshan Hosp, Liver Canc Inst, 180 Feng Lin Rd, Shanghai 200032, Peoples R China.
推荐引用方式 GB/T 7714	Wang, ZC,Liu, LZ,Liu, XY,et al. Genetic polymorphisms of the multidrug resistance 1 gene MDR1 and the risk of hepatocellular carcinoma[J]. TUMOR BIOLOGY,2015,36(9):7007-7015.
APA	Wang, ZC.,Liu, LZ.,Liu, XY.,Hu, JJ.,Wu, YN.,...&Gao, Q .(2015).Genetic polymorphisms of the multidrug resistance 1 gene MDR1 and the risk of hepatocellular carcinoma.TUMOR BIOLOGY,36(9),7007-7015.
MLA	Wang, ZC,et al."Genetic polymorphisms of the multidrug resistance 1 gene MDR1 and the risk of hepatocellular carcinoma".TUMOR BIOLOGY 36.9(2015):7007-7015.