Lipotoxicity, a Potential Risk Factor for the Increasing Prevalence of Subclinical Hypothyroidism?

doi:10.1210/jc.2014-3987

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	Lipotoxicity, a Potential Risk Factor for the Increasing Prevalence of Subclinical Hypothyroidism?
	Zhao, M; Tang, XL; Yang, T; Zhang, BC; Guan, QB; Shao, SS; Xue, FZ; Zhang, X; Liu, ZF; Yuan, ZS
刊名	JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
	2015-05
卷号	100 期号:5 页码:1887-1894
ISSN号	0021-972X
DOI	10.1210/jc.2014-3987
文献子类	Article
英文摘要	Context: Subclinical hypothyroidism (SCH) is an important public health problem worldwide for its increasing prevalence and potential deleterious effects, whereas its etiology has not been fully elucidated. Lipotoxicity exerts extensive and serious impact on human health, but so far, the potential effect of lipotoxicity on thyroid is unclear. Objective: The objective of the study was to assess the association between serum triglyceride levels and the risk for SCH. Design, Participants, and Methods: We conducted a population-based case-control study. A total of 24 100 subjects with similar and stable iodine nutrition status were recruited from China. Cases of 5033 SCH patients were identified and equal controls were matched by age, gender, and region. Conditional logistic regression was used to analyze the association between serum triglyceride levels and risk for SCH. Results: Hypertriglyceridemia was associated with an approximately 35% increased risk for SCH in both men (odds ratio 1.325; 95% confidence interval 1.002-1.753) and women (odds ratio 1.397; 95% confidence interval 1.217-1.604), even after adjustment for potential confounders. Notably, the risk for SCH increased progressively following the elevation of serum triglyceride levels. Compared with individuals with serum triglyceride levels less than 0.97 mmol/L, the risk for SCH increased approximately 1.9-fold in men and 1.4-fold in women, respectively, when triglyceride levels were greater than 1.99 mmol/L. Conclusion: Our findings suggested that hypertriglyceridemia was positively associated with the risk for SCH.
学科主题	Endocrinology & Metabolism
出版地	WASHINGTON
资助项目	国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划（973计划）
项目编号	National Basic Research Program [2012CB524900] ; National Natural Science Foundation [81230018, 81300644, 81270869, 81370891, 81430020] ; Chinese Society of Endocrinology ; National Clinical Research Center for Metabolic Diseases ; Department of Science and Technology of Shandong Province [2012GSF11824]
语种	英语
WOS记录号	WOS:000357669000041
资助机构	NSFC ; MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/178571]
专题	第一临床医学院_期刊论文
通讯作者	Xu, C (reprint author), Shandong Univ, Shandong Prov Hosp, Dept Endocrinol & Metab, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.
推荐引用方式 GB/T 7714	Zhao, M,Tang, XL,Yang, T,et al. Lipotoxicity, a Potential Risk Factor for the Increasing Prevalence of Subclinical Hypothyroidism?[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2015,100(5):1887-1894.
APA	Zhao, M.,Tang, XL.,Yang, T.,Zhang, BC.,Guan, QB.,...&Xu, C .(2015).Lipotoxicity, a Potential Risk Factor for the Increasing Prevalence of Subclinical Hypothyroidism?.JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,100(5),1887-1894.
MLA	Zhao, M,et al."Lipotoxicity, a Potential Risk Factor for the Increasing Prevalence of Subclinical Hypothyroidism?".JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 100.5(2015):1887-1894.