Unexplained infertility patients have increased serum IL-2, IL-4, IL-6, IL-8, IL-21, TNF alpha, IFN gamma and increased Tfh/CD4 T cell ratio: increased Tfh and IL-21 strongly correlate with presence of autoantibodies

doi:10.3109/08820139.2014.932377

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	Unexplained infertility patients have increased serum IL-2, IL-4, IL-6, IL-8, IL-21, TNF alpha, IFN gamma and increased Tfh/CD4 T cell ratio: increased Tfh and IL-21 strongly correlate with presence of autoantibodies
	An, LF; Zhang, XH; Sun, XT; Zhao, LH; Li, S; Wang, WH; Wang, WH (reprint author), Lanzhou Univ, Reprod Med Hosp, Hosp 1, Lanzhou 730000, Peoples R China.
刊名	Immunological Investigations
	2015
卷号	44 期号:2 页码:164-173
关键词	Autoantibody cytokine diagnosis infertility Tfh
ISSN号	0882-0139
DOI	10.3109/08820139.2014.932377
文献子类	Article
英文摘要	Infertility is a disease of the reproductive system that affects millions of people globally. Reproductive failure is a major medical issue adversely affecting human health in the 21st century. Many factors contribute to infertility, including immune conditions which may lead to immune infertility (immunologic infertility). It is known that specific T helper cells (Th) and their cytokines are involved in the stages of infertility. The aim of this study is to provide a new diagnostic approach to immunologic infertility by investigating the correlation of follicular helper T cells (Tfh) and their secreted cytokines with the autoantibodies in peripheral blood samples from immunologically infertile patients. Thirty (30) patients suffering from immune infertility and 20 control subjects were selected as the sample base for this study. The levels of Tfh, 20 cytokines and 4 antibodies were evaluated for this investigation and evaluated using flow cytometry, antibody chip and ELISA technologies. It was found that, in immunologically infertile patients, Tfh cell numbers were significantly higher than those in the control group. Likewise, seven (7) serum cytokines were expressed to a greater degree in infertile patients compared to the control group. Finally, four (4) antibodies were found to be higher in immunologically infertile patients. The results show that, among patients with immunologic infertility, the levels of Tfh cells and IL-21 were increased significantly in peripheral blood samples and correlate positively with the autoantibodies. IL-12 was positively correlated with the two antibodies, while TNF alpha was negatively correlated with two additional antibodies. The detection and quantification of Tfh cells, IL-21, IL-12 and TNFa may provide new diagnostic indicators to screen for immunologic infertility.
学科主题	Immunology
出版地	LONDON
语种	英语
WOS记录号	WOS:000347810900005
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125901]
专题	第一临床医学院_期刊论文
通讯作者	Wang, WH (reprint author), Lanzhou Univ, Reprod Med Hosp, Hosp 1, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	An, LF,Zhang, XH,Sun, XT,et al. Unexplained infertility patients have increased serum IL-2, IL-4, IL-6, IL-8, IL-21, TNF alpha, IFN gamma and increased Tfh/CD4 T cell ratio: increased Tfh and IL-21 strongly correlate with presence of autoantibodies[J]. Immunological Investigations,2015,44(2):164-173.
APA	An, LF.,Zhang, XH.,Sun, XT.,Zhao, LH.,Li, S.,...&Wang, WH .(2015).Unexplained infertility patients have increased serum IL-2, IL-4, IL-6, IL-8, IL-21, TNF alpha, IFN gamma and increased Tfh/CD4 T cell ratio: increased Tfh and IL-21 strongly correlate with presence of autoantibodies.Immunological Investigations,44(2),164-173.
MLA	An, LF,et al."Unexplained infertility patients have increased serum IL-2, IL-4, IL-6, IL-8, IL-21, TNF alpha, IFN gamma and increased Tfh/CD4 T cell ratio: increased Tfh and IL-21 strongly correlate with presence of autoantibodies".Immunological Investigations 44.2(2015):164-173.