Pathogenesis of liver cirrhosis

doi:10.3748/wjg.v20.i23.7312

CORC > 兰州大学 > 兰州大学 > 第一临床医学院 > 期刊论文

	Pathogenesis of liver cirrhosis
	Zhou, WC; Zhang, QB; Qiao, L; Zhou, WC (reprint author), Lanzhou Univ, Hosp 1, Dept Gen Surg 2, 1 Dong Gang Rd, Lanzhou 730000, Gansu, Peoples R China.
刊名	WORLD JOURNAL OF GASTROENTEROLOGY
	2014-06-21
卷号	20 期号:23 页码:7312-7324
关键词	Cirrhosis Pathogenesis Hepatic stellate cells Cytokine miRNA Animal model Therapy
ISSN号	1007-9327
DOI	10.3748/wjg.v20.i23.7312
文献子类	Article
英文摘要	Liver cirrhosis is the final pathological result of various chronic liver diseases, and fibrosis is the precursor of cirrhosis. Many types of cells, cytokines and miRNAs are involved in the initiation and progression of liver fibrosis and cirrhosis. Activation of hepatic stellate cells (HSCs) is a pivotal event in fibrosis. Defenestration and capillarization of liver sinusoidal endothelial cells are major contributing factors to hepatic dysfunction in liver cirrhosis. Activated Kupffer cells destroy hepatocytes and stimulate the activation of HSCs. Repeated cycles of apoptosis and regeneration of hepatocytes contribute to pathogenesis of cirrhosis. At the molecular level, many cytokines are involved in mediation of signaling pathways that regulate activation of HSCs and fibrogenesis. Recently, miRNAs as a post-transcriptional regulator have been found to play a key role in fibrosis and cirrhosis. Robust animal models of liver fibrosis and cirrhosis, as well as the recently identified critical cellular and molecular factors involved in the development of liver fibrosis and cirrhosis will facilitate the development of more effective therapeutic approaches for these conditions. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
学科主题	Gastroenterology & Hepatology
出版地	PLEASANTON
语种	英语
WOS记录号	WOS:000338519800022
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125877]
专题	第一临床医学院_期刊论文
通讯作者	Zhou, WC (reprint author), Lanzhou Univ, Hosp 1, Dept Gen Surg 2, 1 Dong Gang Rd, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Zhou, WC,Zhang, QB,Qiao, L,et al. Pathogenesis of liver cirrhosis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2014,20(23):7312-7324.
APA	Zhou, WC,Zhang, QB,Qiao, L,&Zhou, WC .(2014).Pathogenesis of liver cirrhosis.WORLD JOURNAL OF GASTROENTEROLOGY,20(23),7312-7324.
MLA	Zhou, WC,et al."Pathogenesis of liver cirrhosis".WORLD JOURNAL OF GASTROENTEROLOGY 20.23(2014):7312-7324.